Moderate Cosmetic Ingredient

Dioctyl Maleate

INCI: DIOCTYL MALEATE

CAS Number
142-16-5
Function
Emollient, Solvent
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No FDA restrictions; parent maleic acid cleared as indirect food additive

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Permitted emollient ester with no Annex restrictions, but significant data gaps across all key toxicological endpoints including no peer-reviewed primary safety data, no SCCS opinion, and no CIR review; minority ECHA notifier flags reproductive toxicity Category 2.

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Concern Level: Moderate

Regulatory Flags

reproductive-toxicity-flag-cat2 no-cir-review no-sccs-opinion no-dermal-absorption-data no-sensitization-data commission-studies-recommended

Frequently Asked Questions

Is Dioctyl Maleate safe in cosmetics?

Permitted emollient ester with no Annex restrictions, but significant data gaps across all key toxicological endpoints including no peer-reviewed primary safety data, no SCCS opinion, and no CIR review; minority ECHA notifier flags reproductive toxicity Category 2. The EU classifies Dioctyl Maleate as "permitted". Safety rating: MODERATE.

Is Dioctyl Maleate allowed in the EU?

Dioctyl Maleate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dioctyl Maleate do in cosmetics?

Dioctyl Maleate functions as: Emollient, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 142-16-5.

What is the Margin of Safety for Dioctyl Maleate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Dioctyl Maleate compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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