Good Cosmetic Ingredient

Dipeptide-4

INCI: DIPEPTIDE-4

CAS Number
19246-18-5
Function
Skin conditioning, antioxidant (glutathione-biomimetic), anti-glycation, DNA protection
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No FDA restriction or prohibition. Not subject to OTC GRASE framework. Must be declared on MoCRA product listings. No CIR safety assessment exists for Dipeptide-4 specifically.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Synthetic dipeptide of cysteine and glycine with glutathione-biomimetic properties. EU-permitted as skin conditioning agent without Annex restrictions. US-permitted under MoCRA with product listing requirements. Full toxicological and dermal penetration data must be obtained from supplier for CPSR completion.

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Concern Level: Low

Regulatory Flags

no-sccs-opinion no-cir-assessment cas-discrepancy no-published-mos low-mw-absorption-risk supplier-data-only data-gap-critical

Frequently Asked Questions

Is Dipeptide-4 safe in cosmetics?

Synthetic dipeptide of cysteine and glycine with glutathione-biomimetic properties. EU-permitted as skin conditioning agent without Annex restrictions. US-permitted under MoCRA with product listing requirements. Full toxicological and dermal penetration data must be obtained from supplier for CPSR completion. The EU classifies Dipeptide-4 as "permitted". Safety rating: GOOD.

Is Dipeptide-4 allowed in the EU?

Dipeptide-4 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dipeptide-4 do in cosmetics?

Dipeptide-4 functions as: Skin conditioning, antioxidant (glutathione-biomimetic), anti-glycation, DNA protection. It is classified as a cosmetic ingredient in our database. CAS number: 19246-18-5.

What is the Margin of Safety for Dipeptide-4?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Dipeptide-4 compliance across multiple jurisdictions:

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Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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