Is Dipeptide-4 safe in cosmetics?
Dipeptide-4 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Dipeptide-4
Also known as: Cys-Gly, Glycine, N-L-cysteinyl-, L-Cysteinyl-glycine
INCI: DIPEPTIDE-4
Dipeptide-4 (CAS 19246-18-5) is a cosmetic cosmetic ingredient functioning as Skin conditioning, antioxidant (glutathione-biomimetic), anti-glycation, DNA. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 19246-18-5 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning, antioxidant (glutathione-biomimetic), anti-glycation, DNA protection
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]acetic acid
InChIKey
ZUKPVRWZDMRIEO-VKHMYHEASA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA restriction or prohibition. Not subject to OTC GRASE framework. Must be declared on MoCRA product listings. No CIR safety assessment exists for Dipeptide-4 specifically.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dipeptide-4.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Dipeptide-4.
Regulatory Flags
no-sccs-opinion
no-cir-assessment
cas-discrepancy
no-published-mos
low-mw-absorption-risk
supplier-data-only
data-gap-critical
Known Synonyms
Cys-Gly
Glycine, N-L-cysteinyl-
L-Cysteinyl-glycine
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL371579
Frequently Asked Questions
Is Dipeptide-4 allowed in the EU?
Dipeptide-4 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dipeptide-4 do in cosmetics?
Dipeptide-4 functions as: Skin conditioning, antioxidant (glutathione-biomimetic), anti-glycation, DNA protection. It is classified as a cosmetic ingredient in our database. CAS number: 19246-18-5.
Is Dipeptide-4 used outside cosmetics?
Dipeptide-4 also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dipeptide-4 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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