Poor Cosmetic Ingredient SCCS/CIR Reviewed Sensitization Data

Disperse Blue 1

INCI: DISPERSE BLUE 1

CAS Number
2475-45-8
Function
Hair dyeing (historically)
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status prohibited
US Notes Not approved as a color additive under 21 CFR Parts 73/74; not permitted in cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir Philadelphia 0 1995
Verdict: safe

to the fact that exposure to hair dyes is brief, the Expert Panel concluded that Disperse Blue 1 is safe for use in hair dyes at concentrations up to 1%. CONCLUSION Based on the animal and use data presented in this report, the CIR Expert Panel concludes that Disperse Blue 1 is safe for use in hair

Sensitization Profile

Contact sensitization data for Disperse Blue 1 based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.5%
Cross-reactivity Group
para-amino-group
Reaction Type
contact-dermatitis

Source: IVDK; NACDG; ESSCA

Expert Verdict

Carcinogenic potential; banned in EU cosmetics since Annex II listing; restricted under REACH Annex XVII with concentration limits in textile and leather articles; strong contact allergen.

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Concern Level: High

Regulatory Flags

potential-allergen prop65 eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is Disperse Blue 1 safe in cosmetics?

Carcinogenic potential; banned in EU cosmetics since Annex II listing; restricted under REACH Annex XVII with concentration limits in textile and leather articles; strong contact allergen. The EU classifies Disperse Blue 1 as "prohibited". Safety rating: POOR. This ingredient has been reviewed by cir.

Is Disperse Blue 1 allowed in the EU?

Disperse Blue 1 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Disperse Blue 1 do in cosmetics?

Disperse Blue 1 functions as: Hair dyeing (historically). It is classified as a cosmetic ingredient in our database. CAS number: 2475-45-8.

What is the Margin of Safety for Disperse Blue 1?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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