Is Disperse Blue 1 safe in cosmetics?
Disperse Blue 1 has a safety rating of "POOR" in our database. EU status: prohibited. US status: prohibited. This ingredient has been reviewed by cir.
Disperse Blue 1
Also known as: C.I. Solvent Blue 18, Acetate Blue G, Acetate Blue 6, Acetoquinone Blue R, Acetylon Fast Blue G (+15 more)
INCI: DISPERSE BLUE 1
Disperse Blue 1 (CAS 2475-45-8) is a cosmetic cosmetic ingredient functioning as Hair dyeing (historically). EU Regulation 1223/2009 status: prohibited; 1 safety opinion reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2475-45-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Disperse Blue 1 is prohibited in EU cosmetics but has active industrial GHS classifications (H351, H315, H317, H318, H350, H373).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair dyeing (historically)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
1,4,5,8-tetraaminoanthracene-9,10-dione
InChIKey
JSFUMBWFPQSADC-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
Not approved as a color additive under 21 CFR Parts 73/74; not permitted in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Disperse Blue 1.
Calculate MoS for your specific formulation with the MoS Calculator.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
cir
Philadelphia
0 1995
Verdict: safe
to the fact that exposure to hair dyes is brief, the Expert Panel concluded that Disperse Blue 1 is safe for use in hair dyes at concentrations up to 1%. CONCLUSION Based on the animal and use data presented in this report, the CIR Expert Panel concludes that Disperse Blue 1 is safe for use in hair
Sensitization Profile
Contact sensitization data for Disperse Blue 1 based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.5%
Cross-reactivity Group
para-amino-group
Reaction Type
contact-dermatitis
Source: IVDK; NACDG; ESSCA
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
2B
Volume
48
Evaluation Year
1989
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Health HazardHarmful / IrritantCorrosive
Hazard Class and Category
Carc. 1B; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
Hazard Statements
- H350 May cause cancer
- H315 Causes skin irritation
- H318 Causes serious eye damage
- H317 May cause an allergic skin reaction
Inserted via ATP: CLP00
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 700
(EC) 2009/1223
CMR: Carcinogenic Cat. 1B()
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 700
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| ASEAN | permitted_colorant | - | Not eye area |
| KR | prohibited | - | - |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "dye", "cross_reactivity_group": "para-amino-group", "patch_test_frequency_pct": "0.5", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "IVDK; NACDG; ESSCA"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (3)
Carcinogen Classification
Disperse Blue 1 | Group 2B: Possibly carcinogenic to humans | Volume 48: (1990) Some Flame Retardants and Textile Chemicals, and Exposures in the Textile Manufacturing Industry
Source: International Agency for Research on Cancer (IARC)
Carcinogen Classification
C.I. Disperse blue 1 | TR-299: Toxicology and Carcinogenesis Studies of C.I. Disperse Blue 1 (A commercial dye containing approximately 50% 1,4,5,8-tetraaminoanthraquinone, and 20% water) (CASRN 2475-45-8) in F344/N Rats and B6C3F1 Mice (Feed Studies) (1986 ) | 03/29/85 | Clear Evidence | Clear Evidence | Equivocal Evidence | No Evidence | Under the conditions of these feed studies of C.I
Source: NTP Technical Reports
Evidence for Carcinogenicity
Evaluation: There is sufficient evidence for the carcinogenicity of Disperse Blue 1 in experimental animals. No data were available from studies in humans on the carcinogenicity of Disperse Blue 1. Overall evaluation: Disperse Blue 1 is possibly carcinogenic to humans (Group 2B). | Disperse Blue 1: reasonably anticipated to be a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (3)
California Proposition 65 (OEHHA)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Disperse Blue 1.
Regulatory Flags
potential-allergen
prop65
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
C.I. Solvent Blue 18
Acetate Blue G
Acetate Blue 6
Acetoquinone Blue R
Acetylon Fast Blue G
Amacel Blue GG
Amacel Pure Blue B
Anthraquinone, 1,4,5,8-tetramino-
Artisil Blue SAP
Artisil Blue SAP Conc
Brasilazet Blue GR
BRN 0925672
Celanthrene Pure Blue BRS
Celliton Blue G
Celliton Blue BB-CF
Celliton Blue Extra
Celliton Blue GA-CF
CI Disperse Blue 1
CI Solvent Blue 18
Cibacet Sapphire Blue G
Chemical Function
Dye
Regulatory Lists
banned; Europe; Personal care
OEHHA Proposition 65 (3/2019)
OEHHA Proposition 65 (1/2023)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL87568
Frequently Asked Questions
Is Disperse Blue 1 allowed in the EU?
Disperse Blue 1 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Disperse Blue 1 do in cosmetics?
Disperse Blue 1 functions as: Hair dyeing (historically). It is classified as a cosmetic ingredient in our database. CAS number: 2475-45-8.
Is Disperse Blue 1 used outside cosmetics?
Disperse Blue 1 also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Disperse Blue 1 have different safety status in cosmetics vs industrial chemicals?
Disperse Blue 1 is prohibited in EU cosmetics but has active industrial GHS classifications (H351, H315, H317, H318, H350, H373).
Compliance Tools
Check Disperse Blue 1 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Chemical family
Hair dyeing, textile dyeing
DISODIUM GLUCARATE/GLUCONATE/GLUCURONATE/GLYCOLATE/KETOGLUCONATE/OXALATE/TARTRATE/TARTRONATE
Good
Browse nearby
Chelating
DISODIUM SELENITE
Moderate
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Not Reported
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