Ergosterol Endoperoxide

INCI: ERGOSTEROL ENDOPEROXIDE

CAS Number
2061-64-5 [^1_5]
Function
Skin Conditioning (research-stage) — anti-inflammatory, anti-proliferative, pro-apoptotic activities documented
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not specifically listed under 21 CFR prohibitions/restrictions. No established cosmetic use history; would require substantiation per FD&C Act §601

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Pro-apoptotic and anti-proliferative activity raises concern for topical application on healthy skin cells; no human clinical safety data; not a recognized cosmetic ingredient; sourced from fungi/yeast/lichens with potential for contaminant variability; no CIR or SCCS review.

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Concern Level: High

Frequently Asked Questions

Is Ergosterol Endoperoxide safe in cosmetics?

Pro-apoptotic and anti-proliferative activity raises concern for topical application on healthy skin cells; no human clinical safety data; not a recognized cosmetic ingredient; sourced from fungi/yeast/lichens with potential for contaminant variability; no CIR or SCCS review. The EU classifies Ergosterol Endoperoxide as "permitted". Safety rating: POOR.

Is Ergosterol Endoperoxide allowed in the EU?

Ergosterol Endoperoxide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ergosterol Endoperoxide do in cosmetics?

Ergosterol Endoperoxide functions as: Skin Conditioning (research-stage) — anti-inflammatory, anti-proliferative, pro-apoptotic activities documented. It is classified as a cosmetic ingredient in our database. CAS number: 2061-64-5 [^1_5].

What is the Margin of Safety for Ergosterol Endoperoxide?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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