Poor Cosmetic Ingredient Sensitization Data

Eupatorium Cannabinum Extract

INCI: EUPATORIUM CANNABINUM EXTRACT

CAS Number
84625-34-3
Function
Skin conditioning
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted, not prohibited or restricted; no CIR review

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Eupatorium Cannabinum Extract based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
botanical
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
compositae-group
Reaction Type
contact-dermatitis

Source: IVDK; literature review

Expert Verdict

E. cannabinum (hemp agrimony) is a documented source of unsaturated pyrrolizidine alkaloids (supinine, rinderine), which are hepatotoxic, genotoxic, and potentially carcinogenic; EFSA and BfR have flagged PAs extensively; analytical PA testing required and likely rejection unless PA levels confirmed below detection limits.

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Concern Level: High

Regulatory Flags

plant-extract

Frequently Asked Questions

Is Eupatorium Cannabinum Extract safe in cosmetics?

E. cannabinum (hemp agrimony) is a documented source of unsaturated pyrrolizidine alkaloids (supinine, rinderine), which are hepatotoxic, genotoxic, and potentially carcinogenic; EFSA and BfR have flagged PAs extensively; analytical PA testing required and likely rejection unless PA levels confirmed below detection limits. The EU classifies Eupatorium Cannabinum Extract as "permitted". Safety rating: POOR.

Is Eupatorium Cannabinum Extract allowed in the EU?

Eupatorium Cannabinum Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Eupatorium Cannabinum Extract do in cosmetics?

Eupatorium Cannabinum Extract functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 84625-34-3.

What is the Margin of Safety for Eupatorium Cannabinum Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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