Poor Cosmetic Ingredient NOAEL Data

Fusel Oil

INCI: FUSEL OIL

CAS Number
8013-75-0
Function
Solvent, denaturant
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — no specific CFR cosmetic restriction; individual components regulated separately

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Fusel Oil. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1657 mg/kg bw/day oral rat oral REACH
NOAEL >20 mg/L air 1991 rat inhalation REACH
NOAEL 1068 mg/kg bw/day oral rat oral REACH
NOAEL 10 other oral rat oral REACH
NOEL 316 mg/kg bw/day oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL 2 other other rat oral REACH
NOAEL ca.3250 mg/kg bw/day oral rat oral REACH
NOAEL 9700 mg/kg bw/day oral mouse oral REACH
NOEL 6200 mg/kg bw/day oral monkey oral REACH

Expert Verdict

Multiple GHS hazards including flammability (H226/H225), acute toxicity oral (H302), skin irritation (H315), eye damage (H318), STOT SE 3 narcosis (H336), and respiratory irritation (H335); mixture of isoamyl alcohol, isobutyl alcohol, n-propanol, and ethanol; not recommended for leave-on products; requires robust risk assessment for any cosmetic application.

⚠️
Concern Level: High

Regulatory Flags

plant-oil ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Fusel Oil safe in cosmetics?

Multiple GHS hazards including flammability (H226/H225), acute toxicity oral (H302), skin irritation (H315), eye damage (H318), STOT SE 3 narcosis (H336), and respiratory irritation (H335); mixture of isoamyl alcohol, isobutyl alcohol, n-propanol, and ethanol; not recommended for leave-on products; requires robust risk assessment for any cosmetic application. The EU classifies Fusel Oil as "permitted". Safety rating: POOR. 10 toxicological study endpoint(s) are available in our database.

Is Fusel Oil allowed in the EU?

Fusel Oil EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Fusel Oil do in cosmetics?

Fusel Oil functions as: Solvent, denaturant. It is classified as a cosmetic ingredient in our database. CAS number: 8013-75-0.

What is the Margin of Safety for Fusel Oil?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Fusel Oil?

The NOAEL (No Observed Adverse Effect Level) for Fusel Oil is 1657 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.

Compliance Tools

Check Fusel Oil compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

Dibutyl Oxalate
Moderate
Mixed Terpenes
Moderate
Glycofurol
Moderate
Butyl Hydroxybutyrate
Moderate
Xylene
Poor
Browse all 30,000+ ingredients →
📱

Is Fusel Oil in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Fusel Oil in your formulation.

Ingredient Decoder MoS Calculator