Excellent Cosmetic Ingredient

gamma-Valerolactone

INCI: GAMMA-VALEROLACTONE

CAS Number
108-29-2
Function
Fragrance ingredient with warm, sweet, hay/tobacco-like character; solvent
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — FEMA GRAS; pre-registered for REACH

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Cramer Class I ingredient with no genotoxic or phototoxic potential; metabolized safely with systemic exposure 23× below TTC threshold.

⚠️
Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is gamma-Valerolactone safe in cosmetics?

Cramer Class I ingredient with no genotoxic or phototoxic potential; metabolized safely with systemic exposure 23× below TTC threshold. The EU classifies gamma-Valerolactone as "permitted". Safety rating: EXCELLENT.

Is gamma-Valerolactone allowed in the EU?

gamma-Valerolactone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does gamma-Valerolactone do in cosmetics?

gamma-Valerolactone functions as: Fragrance ingredient with warm, sweet, hay/tobacco-like character; solvent. It is classified as a cosmetic ingredient in our database. CAS number: 108-29-2.

What is the Margin of Safety for gamma-Valerolactone?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check gamma-Valerolactone compliance across multiple jurisdictions:

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Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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