Is gamma-Valerolactone safe in cosmetics?
gamma-Valerolactone has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
EXCELLENT
Cosmetic Ingredient
gamma-Valerolactone
Also known as: 5-17-09-00024, BRN 0080420, EINECS 203-569-5, FEMA No. 3103, 2(3H)-Furanone, dihydr-5-methyl- (+14 more)
INCI: GAMMA-VALEROLACTONE
gamma-Valerolactone (CAS 108-29-2) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient with warm, sweet, hay/tobacco-like character; solvent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
Function
Fragrance ingredient with warm, sweet, hay/tobacco-like character; solvent
Editorial assessment
EXCELLENT
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
5-methyloxolan-2-one
InChIKey
GAEKPEKOJKCEMS-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS; pre-registered for REACH
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for gamma-Valerolactone.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 8250 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
220
Source: WHO/JECFA
JECFA Evaluation
gamma-VALEROLACTONE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/42 | FAS 40-JECFA 49/231
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Editorial summary
Preliminary editorial summary for gamma-Valerolactone — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
5-17-09-00024
BRN 0080420
EINECS 203-569-5
FEMA No. 3103
2(3H)-Furanone, dihydr-5-methyl-
gamma-Methyl-gamma-butyrolactone
Pentanoic acid, 4-hydroxy-, gamma-lactone
Pentanolide-1,4
Valeric acid, 4-hydroxy-, gamma-lactone
gamma-Valeryllactone
gamma-Valerolakton
UNII-O7056XK37X
4-Methyl-4-hydroxybutanoic acid lactone
4-Methyl-g-butyrolactone
4-Methyl-gamma-butyrolactone
4-Valerolactone
5-methyloxolan-2-one
gamma-Pentalactone
gamma-Pentanolactone
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL195593
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
GAMMA-VALEROLACTONE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is gamma-Valerolactone allowed in the EU?
gamma-Valerolactone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does gamma-Valerolactone do in cosmetics?
gamma-Valerolactone functions as: Fragrance ingredient with warm, sweet, hay/tobacco-like character; solvent. It is classified as a cosmetic ingredient in our database. CAS number: 108-29-2.
Is gamma-Valerolactone used outside cosmetics?
gamma-Valerolactone also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check gamma-Valerolactone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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