Gluconolactone / Gluconic Acid

INCI: GLUCONOLACTONE AND GLUCONIC ACID

CAS Number
90-80-2 (Gluconolactone); 526-95-4 (Gluconic Acid)
Function
Chelating agent, skin conditioning agent, humectant, polyhydroxy acid exfoliant
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
EU Max Conc. 15%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR: Safe in present practices of use (Final Report, Sept 2022); FDA GRAS for food (21 CFR 184.1318)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Non-irritating and non-ocular irritant; non-genotoxic and non-teratogenic. As a polyhydroxy acid exfoliant, may mildly increase UV sensitivity at higher use levels; recommend pairing with UV protection.

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Concern Level: Low

Frequently Asked Questions

Is Gluconolactone / Gluconic Acid safe in cosmetics?

Non-irritating and non-ocular irritant; non-genotoxic and non-teratogenic. As a polyhydroxy acid exfoliant, may mildly increase UV sensitivity at higher use levels; recommend pairing with UV protection. The EU classifies Gluconolactone / Gluconic Acid as "permitted". Safety rating: EXCELLENT.

Is Gluconolactone / Gluconic Acid allowed in the EU?

Gluconolactone / Gluconic Acid EU regulatory status: permitted. Maximum allowed concentration: 15%. This is based on EU Regulation 1223/2009 and its amendments.

What does Gluconolactone / Gluconic Acid do in cosmetics?

Gluconolactone / Gluconic Acid functions as: Chelating agent, skin conditioning agent, humectant, polyhydroxy acid exfoliant. It is classified as a cosmetic ingredient in our database. CAS number: 90-80-2 (Gluconolactone); 526-95-4 (Gluconic Acid).

What is the Margin of Safety for Gluconolactone / Gluconic Acid?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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