Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Glutaral. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 45 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| NOAEL | 1500 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 13.5 mg/kg bw/day | oral | dog | Short Term Toxicity | COSMOS_DB |
| NOAEL | 9 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 440 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 68 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 103 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 120 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 100 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 6 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Legacy preservative with confirmed skin sensitization hazard; restricted to 0.1% in EU with aerosol prohibition; CIR restricts leave-on use to trace impurity levels; not suitable for modern formulations due to sensitization liability.
Regulatory Flags
Frequently Asked Questions
Is Glutaral safe in cosmetics?
Legacy preservative with confirmed skin sensitization hazard; restricted to 0.1% in EU with aerosol prohibition; CIR restricts leave-on use to trace impurity levels; not suitable for modern formulations due to sensitization liability. The EU classifies Glutaral as "restricted". Safety rating: POOR. 10 toxicological study endpoint(s) are available in our database.
Is Glutaral allowed in the EU?
Glutaral EU regulatory status: restricted. Maximum allowed concentration: 0.1%. This is based on EU Regulation 1223/2009 and its amendments.
What does Glutaral do in cosmetics?
Glutaral functions as: Preservative, Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 111-30-8.
What is the Margin of Safety for Glutaral?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Glutaral?
The NOAEL (No Observed Adverse Effect Level) for Glutaral is 45 mg/kg bw/day based on a Developmental study via oral route in rabbit. A total of 10 study endpoints are available. Source: COSMOS_DB.
Is Glutaral classified as hazardous under GHS?
Glutaral carries a GHS signal word of "DANGER". Hazard statements: Toxic if swallowed, in contact with skin or if inhaled Causes skin and eye irritation May cause an allergic skin reaction May cause allergy or asthma symptoms or breathing difficulties if inhaled May cause respiratory irritation Very toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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