Glyceryl Diretinoate

INCI: GLYCERYL DIRETINOATE

CAS Number
Not publicly assigned (CosIng ref. exists)
Function
Skin conditioning
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status prohibited
US Notes Not permitted in cosmetics. Tretinoin (all-trans-retinoic acid) is regulated as a prescription drug by FDA. Esters that regenerate tretinoin are classified as drug ingredients, not cosmetic ingredients.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

CMR Category 1B (Reproductive 1B) via parent retinoic acid with teratogenic risk; prohibited in EU Annex II; classified as drug ingredient by FDA; unsuitable for cosmetic formulation without drug-approval pathway.

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Concern Level: High

Frequently Asked Questions

Is Glyceryl Diretinoate safe in cosmetics?

CMR Category 1B (Reproductive 1B) via parent retinoic acid with teratogenic risk; prohibited in EU Annex II; classified as drug ingredient by FDA; unsuitable for cosmetic formulation without drug-approval pathway. The EU classifies Glyceryl Diretinoate as "prohibited". Safety rating: POOR.

Is Glyceryl Diretinoate allowed in the EU?

Glyceryl Diretinoate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Glyceryl Diretinoate do in cosmetics?

Glyceryl Diretinoate functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned (CosIng ref. exists).

What is the Margin of Safety for Glyceryl Diretinoate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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