Poor Cosmetic Ingredient NOAEL Data

Homonopal

INCI: HOMONOPAL

CAS Number
33885-51-7
Function
Fragrance (parfum) — green, floral, aldehydic scent
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes Permitted — no specific CFR restriction (no MoCRA or FDA prohibition at this time)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Homonopal. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=120 mg/kg bw/day oral rat oral REACH

Expert Verdict

ECHA proposed Repr. 1B classification for reproductive toxicity with potential EU consumer cosmetics prohibition; REACH Annex XVII Entry 30 restriction anticipated; aquatic toxicity flagged; IFRA restrictions apply; formulators advised to begin substitution immediately

⚠️
Concern Level: High

Regulatory Flags

fragrance-component ifra_fragrance

Frequently Asked Questions

Is Homonopal safe in cosmetics?

ECHA proposed Repr. 1B classification for reproductive toxicity with potential EU consumer cosmetics prohibition; REACH Annex XVII Entry 30 restriction anticipated; aquatic toxicity flagged; IFRA restrictions apply; formulators advised to begin substitution immediately The EU classifies Homonopal as "restricted". Safety rating: POOR. 1 toxicological study endpoint(s) are available in our database.

Is Homonopal allowed in the EU?

Homonopal EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Homonopal do in cosmetics?

Homonopal functions as: Fragrance (parfum) — green, floral, aldehydic scent. It is classified as a cosmetic ingredient in our database. CAS number: 33885-51-7.

What is the Margin of Safety for Homonopal?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Homonopal?

The NOAEL (No Observed Adverse Effect Level) for Homonopal is >=120 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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