Hornet Venom

INCI: HORNET VENOM

CAS Number
Not assigned
Function
Skin conditioning (anti-aging claims by analogy to bee venom)
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no specific restriction under 21 CFR; no CIR review

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Anaphylaxis risk is the primary concern. Hornetin is a lethal protein (32 kDa, pI 10.2). Unlike bee venom which has some cosmetic safety track record, hornet venom has virtually no published cosmetic safety data. Bee venom cosmetics already report irritation, pruritus, erythema, and urticaria as side effects โ€” hornet venom is significantly more potent. Do not use without comprehensive allergenicity testing and medical disclaimers.

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Hornet Venom safe in cosmetics?

Anaphylaxis risk is the primary concern. Hornetin is a lethal protein (32 kDa, pI 10.2). Unlike bee venom which has some cosmetic safety track record, hornet venom has virtually no published cosmetic safety data. Bee venom cosmetics already report irritation, pruritus, erythema, and urticaria as side effects โ€” hornet venom is significantly more potent. Do not use without comprehensive allergenicity testing and medical disclaimers. The EU classifies Hornet Venom as "prohibited". Safety rating: POOR.

Is Hornet Venom allowed in the EU?

Hornet Venom EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Hornet Venom do in cosmetics?

Hornet Venom functions as: Skin conditioning (anti-aging claims by analogy to bee venom). It is classified as a cosmetic ingredient in our database. CAS number: Not assigned.

What is the Margin of Safety for Hornet Venom?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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