Human Placental Protein

INCI: HUMAN PLACENTAL PROTEIN

CAS Number
91080-00-1
Function
Skin conditioning — humectant
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status restricted
US Notes Not explicitly prohibited; CIR conclusion: insufficient data (2002)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

TSE/viral transmission risk; potential estrogenic activity; FDA historically flagged products containing placental extracts with hormonal claims; CIR requires genotoxicity assay, dermal reproductive/developmental toxicity, and photosensitization data

⚠️
Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Human Placental Protein safe in cosmetics?

TSE/viral transmission risk; potential estrogenic activity; FDA historically flagged products containing placental extracts with hormonal claims; CIR requires genotoxicity assay, dermal reproductive/developmental toxicity, and photosensitization data The EU classifies Human Placental Protein as "prohibited". Safety rating: POOR.

Is Human Placental Protein allowed in the EU?

Human Placental Protein EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Human Placental Protein do in cosmetics?

Human Placental Protein functions as: Skin conditioning — humectant. It is classified as a cosmetic ingredient in our database. CAS number: 91080-00-1.

What is the Margin of Safety for Human Placental Protein?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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