Is Hydrocinnamyl Isobutyrate safe in cosmetics?
Hydrocinnamyl Isobutyrate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Hydrocinnamyl Isobutyrate
Also known as: Propanoic acid, 2-methyl-, 3-phenylpropyl ester, BRN 2454387, EINECS 203-125-0, FEMA No. 2893, Hydrocinnamyl 2-methylpropanoate (+5 more)
INCI: HYDROCINNAMYL ISOBUTYRATE
Hydrocinnamyl Isobutyrate (CAS 103-58-2) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient (sweet, fruity-floral ester). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 103-58-2 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient (sweet, fruity-floral ester)
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
3-phenylpropyl 2-methylpropanoate
InChIKey
VBTAKMZSMFMLGT-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS No. 2893; no CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hydrocinnamyl Isobutyrate.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
2700 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [75] Kligman AM (1975): Report to RIFM, 15 May, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2700 | - | - |
| HMT | - | 0 | 5400 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
640
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3-PHENYLPROPYL 2-METHYLPROPANOATE | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/22 | FAS 46-JECFA 55/79
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3-PHENYLPROPYL ISOBUTYRATE | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/22 | FAS 46-JECFA 55/79
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Hydrocinnamyl Isobutyrate.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
Propanoic acid, 2-methyl-, 3-phenylpropyl ester
BRN 2454387
EINECS 203-125-0
FEMA No. 2893
Hydrocinnamyl 2-methylpropanoate
NSC 404455
Phenylpropyl isobutyrate
Phenylpropyl 2-methylpropanoate, beta-
3-Phenylpropyl 2-methylpropanoate
UNII-Y9O48YFN18
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
3-PHENYLPROPYL ISOBUTYRATE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Hydrocinnamyl Isobutyrate allowed in the EU?
Hydrocinnamyl Isobutyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydrocinnamyl Isobutyrate do in cosmetics?
Hydrocinnamyl Isobutyrate functions as: Fragrance ingredient (sweet, fruity-floral ester). It is classified as a cosmetic ingredient in our database. CAS number: 103-58-2.
Is Hydrocinnamyl Isobutyrate used outside cosmetics?
Hydrocinnamyl Isobutyrate also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hydrocinnamyl Isobutyrate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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