Excellent Emollient NOAEL Data

Hydrogenated Phosphatidylcholine

INCI: HYDROGENATED PHOSPHATIDYLCHOLINE

CAS Number
97281-48-6
Function
Emulsifying, skin conditioning, penetration enhancer
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR Final Report (2015) concluded safe in present practices of use and concentration, superseding 2001 report's 15% concentration cap. Lecithin (parent mixture) is GRAS under 21 CFR 184.1400. Hydrogenated soy lecithin listed as inactive ingredient in inhaled aerosols (pending FDA approval, max 0.28%).

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Hydrogenated Phosphatidylcholine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=3 other 1992 mouse inhalation REACH

Expert Verdict

Endogenous phospholipid with excellent safety profile; CIR-confirmed safe at concentrations up to 50%, with typical cosmetic use up to 5% in leave-on products.

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Concern Level: None

Frequently Asked Questions

Is Hydrogenated Phosphatidylcholine safe in cosmetics?

Endogenous phospholipid with excellent safety profile; CIR-confirmed safe at concentrations up to 50%, with typical cosmetic use up to 5% in leave-on products. The EU classifies Hydrogenated Phosphatidylcholine as "permitted". Safety rating: EXCELLENT. 1 toxicological study endpoint(s) are available in our database.

Is Hydrogenated Phosphatidylcholine allowed in the EU?

Hydrogenated Phosphatidylcholine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydrogenated Phosphatidylcholine do in cosmetics?

Hydrogenated Phosphatidylcholine functions as: Emulsifying, skin conditioning, penetration enhancer. It is classified as a Emollient in our database. CAS number: 97281-48-6.

What is the Margin of Safety for Hydrogenated Phosphatidylcholine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Hydrogenated Phosphatidylcholine?

The NOAEL (No Observed Adverse Effect Level) for Hydrogenated Phosphatidylcholine is >=3 other based on a inhalation study via 1992 route in mouse. Source: REACH.

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