Is Hydroxyethylaminomethyl-p-Aminophenol HCl safe in cosmetics?
Hydroxyethylaminomethyl-p-Aminophenol HCl has a safety rating of "POOR" in our database. EU status: prohibited. US status: restricted.
Poor
Cosmetic Ingredient
Hydroxyethylaminomethyl-p-Aminophenol HCl
Also known as: UNII-663EY8GGFA, Phenol, 4-amino-2-(((2-hydroxyethyl)amino)methyl)-, dihydrochloride, Phenol, 4-amino-2-(((2-hydroxyethyl)amino)methyl)-, hydrochloride (1:2)
INCI: HYDROXYETHYLAMINOMETHYL-P-AMINOPHENOL HCL
Hydroxyethylaminomethyl-p-Aminophenol HCl (CAS 135043-63-9) is a cosmetic cosmetic ingredient functioning as Hair dyeing (oxidative coupler). EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 135043-63-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Hydroxyethylaminomethyl-p-Aminophenol HCl is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H317).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair dyeing (oxidative coupler)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
4-amino-2-[(2-hydroxyethylamino)methyl]phenol;dihydrochloride
InChIKey
AKLWCTDZGBBKNR-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
restricted
US Notes
Not specifically restricted by FDA; however, coal-tar hair dyes carry labeling requirements under 21 CFR 740.17
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hydroxyethylaminomethyl-p-Aminophenol HCl.
Calculate MoS for your specific formulation with the MoS Calculator.
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
ASEAN Cosmetic Directive (II)
Ref:
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Expert Verdict
Expert safety assessment and concern-level summary for Hydroxyethylaminomethyl-p-Aminophenol HCl.
Regulatory Flags
potential-allergen
Known Synonyms
UNII-663EY8GGFA
Phenol, 4-amino-2-(((2-hydroxyethyl)amino)methyl)-, dihydrochloride
Phenol, 4-amino-2-(((2-hydroxyethyl)amino)methyl)-, hydrochloride (1:2)
Chemical Function
Dye
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Hydroxyethylaminomethyl-p-Aminophenol HCl allowed in the EU?
Hydroxyethylaminomethyl-p-Aminophenol HCl EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydroxyethylaminomethyl-p-Aminophenol HCl do in cosmetics?
Hydroxyethylaminomethyl-p-Aminophenol HCl functions as: Hair dyeing (oxidative coupler). It is classified as a cosmetic ingredient in our database. CAS number: 135043-63-9.
Is Hydroxyethylaminomethyl-p-Aminophenol HCl used outside cosmetics?
Hydroxyethylaminomethyl-p-Aminophenol HCl also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Hydroxyethylaminomethyl-p-Aminophenol HCl have different safety status in cosmetics vs industrial chemicals?
Hydroxyethylaminomethyl-p-Aminophenol HCl is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H317).
Compliance Tools
Check Hydroxyethylaminomethyl-p-Aminophenol HCl compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acid Blue 9
Excellent
Same category
Colorant, Hair Dyeing
Acid Blue 9 Aluminum Lake
Excellent
Same category
Colorant
Anthocyanins
Excellent
Same category
Colorant
Beta Vulgaris Extract
Excellent
Same category
Skin Conditioning, Colorant (betalain...
Beta Vulgaris Root Extract
Excellent
Same category
Skin Conditioning, Colorant (betanin/...
Beta Vulgaris Root Powder
Excellent
Same category
Skin conditioning, natural colorant, ...
1,3-Bis-(Isocyanatomethyl) Cyclohexane
Poor
Similar safety
Monomer / cross-linking agent used in...
1,4-Butanediol
Poor
Similar safety
Solvent, humectant, viscosity control...
1,6-Hexamethylene Diisocyanate (HDI)
Poor
Similar safety
Monomer and crosslinker in polymer sy...
1,6-Hexanediamine
Poor
Similar safety
Industrial chemical (nylon monomer); ...
1-Nitropropane
Poor
Similar safety
None in cosmetics - industrial solven...
2,2'-Thiobis(4-Chlorophenol)
Poor
Similar safety
Antimicrobial / antifungal agent
HYDRASTIS CANADENSIS EXTRACT
Good
Browse nearby
Fragrance, Skin Conditioning
HYDRATROPIC ALDEHYDE
Good
Browse nearby
Perfuming
HYDROCHLOROFLUOROCARBON 142B
Good
Browse nearby
Deodorant, Propellant
Is Hydroxyethylaminomethyl-p-Aminophenol HCl in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Hydroxyethylaminomethyl-p-Aminophenol HCl in your formulation.