Poor Cosmetic Ingredient NOAEL Data GHS Classified

Hydroxylamine Sulfate

INCI: HYDROXYLAMINE SULFATE

CAS Number
10039-54-0
Function
Antioxidant
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not specifically prohibited under 21 CFR for cosmetics; permitted by default but flagged by GHS classification

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for Hydroxylamine Sulfate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 5 ppm oral rat oral REACH
NOAEL >0.9 mg/kg bw/day oral rat oral REACH
NOAEL 25 ppm oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes and skin. The substance may cause effects on the blood. This may result in the formation of methaemoglobin.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the blood. This may result in anaemia.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

Expert Verdict

Suspected carcinogen with positive mouse lymphoma assay results; corrosive, harmful via oral and dermal routes with serious eye irritation potential and environmental toxicity concerns.

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Concern Level: High

Frequently Asked Questions

Is Hydroxylamine Sulfate safe in cosmetics?

Suspected carcinogen with positive mouse lymphoma assay results; corrosive, harmful via oral and dermal routes with serious eye irritation potential and environmental toxicity concerns. The EU classifies Hydroxylamine Sulfate as "permitted". Safety rating: POOR. 3 toxicological study endpoint(s) are available in our database.

Is Hydroxylamine Sulfate allowed in the EU?

Hydroxylamine Sulfate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydroxylamine Sulfate do in cosmetics?

Hydroxylamine Sulfate functions as: Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 10039-54-0.

What is the Margin of Safety for Hydroxylamine Sulfate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Hydroxylamine Sulfate?

The NOAEL (No Observed Adverse Effect Level) for Hydroxylamine Sulfate is 5 ppm based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.

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