Is Hydroxylamine Sulfate safe in cosmetics?
Hydroxylamine Sulfate has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Hydroxylamine Sulfate
Also known as: EINECS 233-118-8, UNII-49KP498D4O
INCI: HYDROXYLAMINE SULFATE
Hydroxylamine Sulfate (CAS 10039-54-0) is a cosmetic cosmetic ingredient functioning as Antioxidant. NOAEL 0.4 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 10039-54-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Hydroxylamine Sulfate is classified GHS Danger (H290, H302, H312, H315, H317, H319, H351, H373) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antioxidant
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
hydroxyazanium;sulfate
InChIKey
VGYYSIDKAKXZEE-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically prohibited under 21 CFR for cosmetics; permitted by default but flagged by GHS classification
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hydroxylamine Sulfate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Hydroxylamine Sulfate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.4 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =3 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes and skin. The substance may cause effects on the blood. This may result in the formation of methaemoglobin.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the blood. This may result in anaemia.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Hydroxylamine Sulfate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
0898
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Chemical reaction regulator
UV stabilizer
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Hydroxylamine Sulfate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Hydroxylamine Sulfate by CAS number or substance name.
Studies
2
Lowest NOAEL
0.4 mg/kg bw/day
Highest NOAEL
3 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
EINECS 233-118-8
UNII-49KP498D4O
Chemical Function
Antioxidant
Chemical reaction regulator
UV stabilizer
Regulatory Lists
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Hydroxylamine Sulfate allowed in the EU?
Hydroxylamine Sulfate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydroxylamine Sulfate do in cosmetics?
Hydroxylamine Sulfate functions as: Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 10039-54-0.
What is the NOAEL for Hydroxylamine Sulfate?
The NOAEL (No Observed Adverse Effect Level) for Hydroxylamine Sulfate is =0.4 mg/kg bw/day based on a chronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Hydroxylamine Sulfate used outside cosmetics?
Hydroxylamine Sulfate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Hydroxylamine Sulfate have different safety status in cosmetics vs industrial chemicals?
Hydroxylamine Sulfate is classified GHS Danger (H290, H302, H312, H315, H317, H319, H351, H373) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Hydroxylamine Sulfate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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