Is Isobutyl Acetate safe in cosmetics?
Isobutyl Acetate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Isobutyl Acetate
Also known as: Acetic acid, 2-methylpropyl ester, 4-02-00-00149, BRN 1741909, EINECS 203-745-1, FEMA No. 2175 (+9 more)
Isobutyl Acetate (CAS 110-19-0) is a cosmetic cosmetic ingredient functioning as Flavouring and nutrient; Fragrance; No specific technical function; Solvent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
Cross-Vertical Regulatory Divergence
Isobutyl Acetate is classified GHS Danger (H225, H336, H316, H320, H333) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Flavouring and nutrient; Fragrance; No specific technical function; Solvent
Editorial assessment
EXCELLENT
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
2-methylpropyl acetate
InChIKey
GJRQTCIYDGXPES-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS (No. 2175); no CFR restriction for cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isobutyl Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The vapour is mildly irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause lowering of consciousness.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 1350 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
0494
Source: WHO/JECFA
Skin Eye Respiratory Irritation
A skin and eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Number
137
Source: WHO/JECFA
JECFA Evaluation
ISOBUTYL ACETATE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/52 | FAS 40-JECFA 49/297
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
No specific technical function
Solvent
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Editorial summary
Preliminary editorial summary for Isobutyl Acetate — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
fragrance-component
epa_safer_alternative
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Isobutyl Acetate by CAS number or substance name.
Studies
9
Lowest NOAEL
316 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ECHA
Known Synonyms
Acetic acid, 2-methylpropyl ester
4-02-00-00149
BRN 1741909
EINECS 203-745-1
FEMA No. 2175
FEMA Number 2175
beta-Methylpropyl ethanoate
Isobutylester kyseliny octove
UNII-7CR47FO6LF
2-methylpropyl ethanoate
Essigsaeureisobutylester
Isobutylazetat
i-butyl acetate
isobutyl ethanoate
Chemical Function
Solvent
Fragrance
No specific technical function
Flavouring and nutrient
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Australia; Food and drug - smoking-related products
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ACETIC ACID ISOBUTYL ESTER
ChEMBL ID
CHEMBL46999
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
ISOBUTYL ACETATE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Isobutyl Acetate allowed in the EU?
Isobutyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isobutyl Acetate do in cosmetics?
Isobutyl Acetate functions as: Flavouring and nutrient; Fragrance; No specific technical function; Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 110-19-0.
Is Isobutyl Acetate used outside cosmetics?
Isobutyl Acetate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Isobutyl Acetate have different safety status in cosmetics vs industrial chemicals?
Isobutyl Acetate is classified GHS Danger (H225, H336, H316, H320, H333) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Isobutyl Acetate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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