Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Isobutyric Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | 316 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 375 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 610 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
RIFM comprehensive safety assessment found no safety concerns for skin sensitization at current declared use levels; exposure below DST; not expected to be phototoxic/photoallergenic; no genotoxicity concern; screening-level PEC/PNEC < 1, indicating low aquatic environmental risk. Short-chain branched carboxylic acid (2-methylpropanoic acid); pungent, cheese-like odor in concentrated form; IFRA-compliant (51st Amendment confirmed); propionic acid and isovaleric acid serve as read-across analo...
Regulatory Flags
Frequently Asked Questions
Is Isobutyric Acid safe in cosmetics?
RIFM comprehensive safety assessment found no safety concerns for skin sensitization at current declared use levels; exposure below DST; not expected to be phototoxic/photoallergenic; no genotoxicity concern; screening-level PEC/PNEC < 1, indicating low aquatic environmental risk. Short-chain branched carboxylic acid (2-methylpropanoic acid); pungent, cheese-like odor in concentrated form; IFRA-compliant (51st Amendment confirmed); propionic acid and isovaleric acid serve as read-across analo... The EU classifies Isobutyric Acid as "permitted". Safety rating: MODERATE. 4 toxicological study endpoint(s) are available in our database.
Is Isobutyric Acid allowed in the EU?
Isobutyric Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isobutyric Acid do in cosmetics?
Isobutyric Acid functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 79-31-2.
What is the Margin of Safety for Isobutyric Acid?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Isobutyric Acid?
The NOAEL (No Observed Adverse Effect Level) for Isobutyric Acid is 316 mg/kg bw/day based on a oral study via oral route in rat. A total of 4 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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