Isodon Serra Leaf/Stem Extract

INCI: ISODON SERRA LEAF/STEM EXTRACT

CAS Number
Not confirmed in publicly available databases
Function
Skin conditioning
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no specific CFR restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

I. serra contains anti-tumor diterpenoids with potential cytotoxic activity; cosmetic safety cannot be extrapolated from pharmacological literature; no CIR, SCCS, or RIFM review exists; comprehensive toxicology assessment would be required for regulatory approval.

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Concern Level: High

Regulatory Flags

plant-extract

Frequently Asked Questions

Is Isodon Serra Leaf/Stem Extract safe in cosmetics?

I. serra contains anti-tumor diterpenoids with potential cytotoxic activity; cosmetic safety cannot be extrapolated from pharmacological literature; no CIR, SCCS, or RIFM review exists; comprehensive toxicology assessment would be required for regulatory approval. The EU classifies Isodon Serra Leaf/Stem Extract as "permitted". Safety rating: POOR.

Is Isodon Serra Leaf/Stem Extract allowed in the EU?

Isodon Serra Leaf/Stem Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Isodon Serra Leaf/Stem Extract do in cosmetics?

Isodon Serra Leaf/Stem Extract functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not confirmed in publicly available databases.

What is the Margin of Safety for Isodon Serra Leaf/Stem Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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