Isodonis Japonicus Leaf/Stalk Extract

INCI: ISODONIS JAPONICUS LEAF/STALK EXTRACT

CAS Number
246536-68-5
Function
Masking agent
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no specific CFR restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Isodon japonicus contains enmein and other bioactive diterpenoids with documented pharmacological activity but lacks cosmetic safety assessment; no CIR/SCCS review available and tox data required for CPSR evaluation.

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Concern Level: High

Regulatory Flags

plant-extract

Frequently Asked Questions

Is Isodonis Japonicus Leaf/Stalk Extract safe in cosmetics?

Isodon japonicus contains enmein and other bioactive diterpenoids with documented pharmacological activity but lacks cosmetic safety assessment; no CIR/SCCS review available and tox data required for CPSR evaluation. The EU classifies Isodonis Japonicus Leaf/Stalk Extract as "permitted". Safety rating: POOR.

Is Isodonis Japonicus Leaf/Stalk Extract allowed in the EU?

Isodonis Japonicus Leaf/Stalk Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Isodonis Japonicus Leaf/Stalk Extract do in cosmetics?

Isodonis Japonicus Leaf/Stalk Extract functions as: Masking agent. It is classified as a cosmetic ingredient in our database. CAS number: 246536-68-5.

What is the Margin of Safety for Isodonis Japonicus Leaf/Stalk Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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