Is Isopropylamine safe in cosmetics?
Isopropylamine has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
Isopropylamine
Also known as: 2-Propanamine, EINECS 200-860-9, Propanal, 2-amino-, 2-Amino-propaan, 2-Aminopropan (+3 more)
INCI: ISOPROPYLAMINE
Isopropylamine (CAS 75-31-0) is a cosmetic cosmetic ingredient functioning as pH adjuster / buffering agent. EU Regulation 1223/2009 status: prohibited; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 75-31-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Isopropylamine is prohibited in EU cosmetics but has active industrial GHS classifications (H224, H301, H311, H331, H314, H315, H318, H319).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
pH adjuster / buffering agent
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
propan-2-amine
InChIKey
JJWLVOIRVHMVIS-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted; no specific 21 CFR cosmetic restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isopropylamine.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
FlamFlameSkullToxicCorrCancerHealth haz
Hazard Statements
Extremely flammable liquid and vapour Toxic if swallowed, in contact with skin or if inhaled Causes severe skin burns and eye damage Causes damage to respiratory tract May be harmful if swallowed and enters airways Harmful to aquatic life
Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. If swallowed the substance easily enters the airways and could result in aspiration pneumonitis. Exposure above the OEL could cause death.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis.
Routes of Exposure
Serious local effects by all routes of exposure.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
FlammableHarmful / Irritant
Hazard Class and Category
Flam. Liq. 1; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2
Hazard Statements
- H224 Extremely flammable liquid and vapour
- H335 May cause respiratory irritation
- H315 Causes skin irritation
- H319 Causes serious eye irritation
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
0908
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Complaints of nose and throat irritation were reported by volunteer subjects after brief exposures at 10 to 20 ppm. | Workers complained of transient visual disturbances (halos around lights) after exposure to the vapor for 8 hours, probably resulting from mild corneal edema, which usually cleared in 3 to 4 hours. | Irritating to skin, eyes, and respiratory system. | A severe skin and eye irritant
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (3)
JECFA Number
1581
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-AMINOPROPANE | 2008 | No safety concern at current levels of intake when used as a flavouring agent | ">TRS 934-JECFA 65/89 | ">FAS 60-JECFA 69/630
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ISOPROPYLAMINE | 2008 | No safety concern at current levels of intake when used as a flavouring agent | ">TRS 934-JECFA 65/89 | ">FAS 60-JECFA 69/630
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
pH regulating agent
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Isopropylamine.
Regulatory Flags
fda_food_additive
jecfa_safe
Known Synonyms
2-Propanamine
EINECS 200-860-9
Propanal, 2-amino-
2-Amino-propaan
2-Aminopropan
2-Amino-propano
UNII-P8W26T4MTD
Isopropyl amine
Chemical Function
pH regulating agent
Flavouring and nutrient
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ISOPROPYLAMINE
ChEMBL ID
CHEMBL117080
Frequently Asked Questions
Is Isopropylamine allowed in the EU?
Isopropylamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Isopropylamine do in cosmetics?
Isopropylamine functions as: pH adjuster / buffering agent. It is classified as a cosmetic ingredient in our database. CAS number: 75-31-0.
Is Isopropylamine classified as hazardous under GHS?
Isopropylamine carries a GHS signal word of "DANGER". Hazard statements: Extremely flammable liquid and vapour Toxic if swallowed, in contact with skin or if inhaled Causes severe skin burns and eye damage Causes damage to respiratory tract May be harmful if swallowed and enters airways Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Isopropylamine used outside cosmetics?
Isopropylamine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Isopropylamine have different safety status in cosmetics vs industrial chemicals?
Isopropylamine is prohibited in EU cosmetics but has active industrial GHS classifications (H224, H301, H311, H331, H314, H315, H318, H319).
Compliance Tools
Check Isopropylamine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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ACETALDEHYDE
Moderate
Chemical family
Fragrance
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Chemical family
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DICHLOROMETHANE
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Chemical family
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