Poor Cosmetic Ingredient GHS Classified

Isopropylamine

INCI: ISOPROPYLAMINE

CAS Number
75-31-0
Function
pH adjuster / buffering agent
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes Permitted; no specific 21 CFR cosmetic restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
DANGER
Pictograms
flam;flame; skull;toxic; corr; cancer;health haz
Hazard Statements
Extremely flammable liquid and vapour Toxic if swallowed, in contact with skin or if inhaled Causes severe skin burns and eye damage Causes damage to respiratory tract May be harmful if swallowed and enters airways Harmful to aquatic life
Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. If swallowed the substance easily enters the airways and could result in aspiration pneumonitis. Exposure above the OEL could cause death.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis.
Routes of Exposure
Serious local effects by all routes of exposure.

Expert Verdict

Corrosive (H314 — severe skin burns, eye damage); toxic via oral/dermal/inhalation (H301+H311+H331); extremely flammable (H224); nitrosamine formation risk when combined with nitrosating agents

⚠️
Concern Level: High

Regulatory Flags

fda_food_additive jecfa_safe

Frequently Asked Questions

Is Isopropylamine safe in cosmetics?

Corrosive (H314 — severe skin burns, eye damage); toxic via oral/dermal/inhalation (H301+H311+H331); extremely flammable (H224); nitrosamine formation risk when combined with nitrosating agents The EU classifies Isopropylamine as "prohibited". Safety rating: POOR.

Is Isopropylamine allowed in the EU?

Isopropylamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Isopropylamine do in cosmetics?

Isopropylamine functions as: pH adjuster / buffering agent. It is classified as a cosmetic ingredient in our database. CAS number: 75-31-0.

What is the Margin of Safety for Isopropylamine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Is Isopropylamine classified as hazardous under GHS?

Isopropylamine carries a GHS signal word of "DANGER". Hazard statements: Extremely flammable liquid and vapour Toxic if swallowed, in contact with skin or if inhaled Causes severe skin burns and eye damage Causes damage to respiratory tract May be harmful if swallowed and enters airways Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check Isopropylamine compliance across multiple jurisdictions:

🔬
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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