Good Active Ingredient

Kojic Dipalmitate

INCI: KOJIC DIPALMITATE

CAS Number
79725-98-7
Function
Lipophilic dipalmitoyl ester of kojic acid. Converted to free kojic acid by cutaneous esterases after penetration. Greater photostability and formulation stability than parent kojic acid. Reduced sensitization risk at equivalent brightening doses. Preferred alternative to kojic acid for leave-on formulations and sensitive skin. Tyrosinase inhibitor and radiance active.
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted without restriction. Not listed under Annex III, which covers kojic acid only. Ester pro-drug of kojic acid with reduced systemic exposure versus parent compound. MoCRA safety substantiation required.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Kojic dipalmitate is a preferred formulation-friendly alternative to kojic acid with greater photostability, EU Annex III non-compliance not required, lower sensitization risk, and better compatibility with oil phases. Enzymatic hydrolysis to free kojic acid in skin maintains tyrosinase-inhibition activity.

⚠️
Concern Level: Low

Regulatory Flags

hyperpigmentation tyrosinase-inhibitor radiance fermented-source improved-stability lower-sensitization

Frequently Asked Questions

Is Kojic Dipalmitate safe in cosmetics?

Kojic dipalmitate is a preferred formulation-friendly alternative to kojic acid with greater photostability, EU Annex III non-compliance not required, lower sensitization risk, and better compatibility with oil phases. Enzymatic hydrolysis to free kojic acid in skin maintains tyrosinase-inhibition activity. The EU classifies Kojic Dipalmitate as "permitted". Safety rating: GOOD.

Is Kojic Dipalmitate allowed in the EU?

Kojic Dipalmitate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Kojic Dipalmitate do in cosmetics?

Kojic Dipalmitate functions as: Lipophilic dipalmitoyl ester of kojic acid. Converted to free kojic acid by cutaneous esterases after penetration. Greater photostability and formulation stability than parent kojic acid. Reduced sensitization risk at equivalent brightening doses. Preferred alternative to kojic acid for leave-on formulations and sensitive skin. Tyrosinase inhibitor and radiance active.. It is classified as a Active Ingredient in our database. CAS number: 79725-98-7.

What is the Margin of Safety for Kojic Dipalmitate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Kojic Dipalmitate compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

Sodium Ascorbyl Phosphate
Excellent
Phytonadione
Good
Quercetin
Good
Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract)
Good
Dead Sea Salt
Good
Browse all 30,000+ ingredients →
📱

Is Kojic Dipalmitate in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Kojic Dipalmitate in your formulation.

Ingredient Decoder MoS Calculator