Regulatory Status
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Safety Data
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Dermal Penetration Profile
Skin absorption and penetration characteristics of Madecassic Acid, relevant to systemic exposure and MoS calculations.
Source: Int Wound J 2016
Expert Verdict
Madecassic acid is the triterpenoid aglycone of madecassoside and the lipophilic delivery-optimised form for Centella asiatica anti-inflammatory and collagen-synthesis activity, acting through TGF-beta/Smad ECM anabolism, NF-kB suppression, and JAK/STAT3 attenuation with demonstrated UVB photoprotective activity; CIR concludes safe in present practices of use.
Regulatory Flags
Frequently Asked Questions
Is Madecassic Acid safe in cosmetics?
Madecassic acid is the triterpenoid aglycone of madecassoside and the lipophilic delivery-optimised form for Centella asiatica anti-inflammatory and collagen-synthesis activity, acting through TGF-beta/Smad ECM anabolism, NF-kB suppression, and JAK/STAT3 attenuation with demonstrated UVB photoprotective activity; CIR concludes safe in present practices of use. The EU classifies Madecassic Acid as "permitted". Safety rating: GOOD.
Is Madecassic Acid allowed in the EU?
Madecassic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Madecassic Acid do in cosmetics?
Madecassic Acid functions as: Triterpenoid pentacyclic acid; aglycone of madecassoside from Centella asiatica. Active via TGF-beta/Smad-driven extracellular matrix anabolism: upregulates collagen I, fibronectin, and hydroxyproline synthesis; attenuates NF-kB and JAK/STAT3 inflammatory signaling. Complementary to asiatic acid in the Centella triterpenoid quartet. Photoprotective: protects against UVB-induced keratinocyte apoptosis via Ca2+/AMPK- and mTOR-dependent ERK phosphorylation pathways. Wound healing, barrier resilience, and anti-aging active.. It is classified as a Active Ingredient in our database. CAS number: 18449-41-7.
What is the Margin of Safety for Madecassic Acid?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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