Regulatory Status
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Safety Data
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Expert Verdict
CIR 2016 concluded data are insufficient to determine safety. This ingredient is a direct tissue extract (not a controlled cell culture), and CIR lacked adequate composition, manufacturing, impurity, and toxicological data to clear it. A CPSR relying on this ingredient must include supplier-specific safety testing (irritation, sensitization, genotoxicity at minimum) or reformulate with the Fruit Cell Culture Extract instead.
Regulatory Flags
Frequently Asked Questions
Is Malus Domestica Callus Extract safe in cosmetics?
CIR 2016 concluded data are insufficient to determine safety. This ingredient is a direct tissue extract (not a controlled cell culture), and CIR lacked adequate composition, manufacturing, impurity, and toxicological data to clear it. A CPSR relying on this ingredient must include supplier-specific safety testing (irritation, sensitization, genotoxicity at minimum) or reformulate with the Fruit Cell Culture Extract instead. The EU classifies Malus Domestica Callus Extract as "permitted". Safety rating: POOR.
Is Malus Domestica Callus Extract allowed in the EU?
Malus Domestica Callus Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Malus Domestica Callus Extract do in cosmetics?
Malus Domestica Callus Extract functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned.
What is the Margin of Safety for Malus Domestica Callus Extract?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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