Is Methoxyisopropanol safe in cosmetics?
Methoxyisopropanol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 4 toxicological study endpoint(s) are available in our database.
Methoxyisopropanol
Also known as: Propylene glycol monomethyl ether, 3-01-00-02146, BRN 1731270, EINECS 203-539-1, Methyl proxitol (+5 more)
INCI: METHOXYISOPROPANOL
Methoxyisopropanol (CAS 107-98-2) is a cosmetic cosmetic ingredient functioning as Fragrance, solvent, viscosity-decreasing agent. Reported NOAEL =919 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 107-98-2 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance, solvent, viscosity-decreasing agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-methoxypropan-2-ol
InChIKey
ARXJGSRGQADJSQ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed; also listed as indirect food additive (21 CFR 175.105)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Methoxyisopropanol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Methoxyisopropanol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =919 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =1838 mg/kg bw/day | dermal | Rabbit | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =1885 mg/kg bw/day | oral | Mouse | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =4600 mg/kg bw/day | dermal | Rabbit | subchronic | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance and the vapour in high concentrations are irritating to the eyes, skin and respiratory tract. Exposure to very high concentrations could cause depression of the central nervous system.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol or vapour, through the skin and by ingestion.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
FlammableHarmful / Irritant
Hazard Class and Category
Flam. Liq. 3; STOT SE 3
Hazard Statements
- H226 Flammable liquid and vapour
- H336 May cause drowsiness or dizziness
Inserted via ATP: ATP01
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100,000 - 1,000,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (4)
Evidence for Carcinogenicity
A4: Not classifiable as a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
ICSC Safety Card
0551
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Hazard warning: ...it would appear that likelihood of injury from industry use is remote, especially since its warning property from irritation of mucous membranes by toxic concn makes it improbable that these would be tolerated. | There is no unfavorable human experience known other than from the disagreeableness of the odor and irritation associated with extremely high exposure. Groups of male v
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chemical reaction regulator
Coalescing agent
Dispersing agent
Fragrance
No specific technical function
Solubility enhancer
Solvent
Surfactant (surface active agent)
Viscosity modifier
Regulatory List Membership (3)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Methoxyisopropanol.
Regulatory Flags
fragrance-component
epa_safer_alternative
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Methoxyisopropanol by CAS number or substance name.
Studies
4
Lowest NOAEL
919 mg/kg bw/day
Highest NOAEL
4600 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Propylene glycol monomethyl ether
3-01-00-02146
BRN 1731270
EINECS 203-539-1
Methyl proxitol
Poly-Solve MPM
Propasol solvent M
Ucar Solvent LM (Obs.)
UNII-74Z7JO8V3U
PM glycol ether
Chemical Function
Solvent
Fragrance
Viscosity modifier
Surfactant (surface active agent)
Regulatory Lists
detected; Europe; Vehicle - car interior
detected; Europe; Vehicle - car interior
air; detected; emissions; Europe; Toys and children's products
inert_ingredient; non_food_use; Pesticides
air; Cons electronics mech appliances and machinery; detected; emissions; Europe
Cleaning products and household care - shoes; Europe
Cleaning products and household care - shoes; Europe
artificial_saliva; detected; emissions; Europe; Toys and children's products
air; detected; emissions; Europe; Toys and children's products
Europe; Vehicle - car interior
air; detected; emissions; Europe; Vehicle - car interior
air; detected; emissions; Europe; Vehicle - car interior
air; detected; emissions; Europe; Vehicle - car interior
air; detected; emissions; Europe; Vehicle - car interior
air; detected; emissions; Europe; Vehicle - car interior
air; detected; emissions; Europe; Toys and children's products
air; detected; emissions; Europe; Toys and children's products
SCIL (9/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3186306
Frequently Asked Questions
Is Methoxyisopropanol allowed in the EU?
Methoxyisopropanol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methoxyisopropanol do in cosmetics?
Methoxyisopropanol functions as: Fragrance, solvent, viscosity-decreasing agent. It is classified as a cosmetic ingredient in our database. CAS number: 107-98-2.
What is the NOAEL for Methoxyisopropanol?
The NOAEL (No Observed Adverse Effect Level) for Methoxyisopropanol is =919 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 4 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Methoxyisopropanol used outside cosmetics?
Methoxyisopropanol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Methoxyisopropanol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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