Moderate Cosmetic Ingredient GHS Classified

Methoxyisopropanol

INCI: METHOXYISOPROPANOL

CAS Number
107-98-2
Function
Fragrance, solvent, viscosity-decreasing agent
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Allowed; also listed as indirect food additive (21 CFR 175.105)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance and the vapour in high concentrations are irritating to the eyes, skin and respiratory tract. Exposure to very high concentrations could cause depression of the central nervous system.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol or vapour, through the skin and by ingestion.

Expert Verdict

CIR assessed as safe for nail care products only at 4-35% concentration; volatile - inhalation possible but odor becomes objectionable at 50-75 ppm; margin of safety of 500 based on reproductive toxicity NOAEL. Also known as propylene glycol monomethyl ether (PGME); absorption through nail plate is low

⚠️
Concern Level: High

Regulatory Flags

fragrance-component epa_safer_alternative ifra_fragrance

Frequently Asked Questions

Is Methoxyisopropanol safe in cosmetics?

CIR assessed as safe for nail care products only at 4-35% concentration; volatile - inhalation possible but odor becomes objectionable at 50-75 ppm; margin of safety of 500 based on reproductive toxicity NOAEL. Also known as propylene glycol monomethyl ether (PGME); absorption through nail plate is low The EU classifies Methoxyisopropanol as "permitted". Safety rating: MODERATE.

Is Methoxyisopropanol allowed in the EU?

Methoxyisopropanol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methoxyisopropanol do in cosmetics?

Methoxyisopropanol functions as: Fragrance, solvent, viscosity-decreasing agent. It is classified as a cosmetic ingredient in our database. CAS number: 107-98-2.

What is the Margin of Safety for Methoxyisopropanol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Methoxyisopropanol compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

Trimethyldodecatrien-3-yl Acetate
Good
Spearmint Extract
Good
Iris Versicolor Extract
Moderate
Xanthorrhoea Preissii Leaf Oil
Good
Decyl Isovalerate
Good
Browse all 30,000+ ingredients →
📱

Is Methoxyisopropanol in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Methoxyisopropanol in your formulation.

Ingredient Decoder MoS Calculator