Good Cosmetic Ingredient SCCS/CIR Reviewed

Nano-Hydroxyapatite

INCI: HYDROXYAPATITE

CAS Number
1306-06-5
Function
abrasive, bulking agent, skin conditioning agent, and oral care agent in cosmetic products
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No specific restrictions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

sccs SCCS/1677/25 26 June 2025
Verdict: safe
Max Concentration: 29.5% in oral care

osure conditions? Based on the data provided, the SCCS considers hydroxyapatite (nano) safe when used at concentrations up to 29.5% in toothpaste, and up to 10% in mouthwash. This conclusion is based on the available evidence, which shows that hydroxyapatite (nano) does not pose a mut

sccs SCCS/1677/25 26 June 2025
Verdict: safe
Max Concentration: 10% in oral care

osure conditions? Based on the data provided, the SCCS considers hydroxyapatite (nano) safe when used at concentrations up to 29.5% in toothpaste, and up to 10% in mouthwash. This conclusion is based on the available evidence, which shows that hydroxyapatite (nano) does not pose a mut

sccs SCCS/1677/25 26 June 2025
Verdict: safe
Max Concentration: 0.465% in oral care

osure conditions? Based on the data provided, the SCCS considers hydroxyapatite (nano) safe when used at concentrations up to 29.5% in toothpaste, and up to 10% in mouthwash. This conclusion is based on the available evidence, which shows that hydroxyapatite (nano) does not pose a mut

sccs SCCS/1648/22 22 March 2023
Verdict: safe
Max Concentration: 10% in oral care

posure conditions? Based on the data provided, the SCCS considers hydroxyapatite (nano) safe when used at concentrations up to 10% in toothpaste, and up to 0.465% in mouthwash. This safety evaluation only applies to the hydroxyapatite (nano) with the following characteristics: - compo

sccs SCCS/1648/22 22 March 2023
Verdict: safe
Max Concentration: 0.465% in oral care

posure conditions? Based on the data provided, the SCCS considers hydroxyapatite (nano) safe when used at concentrations up to 10% in toothpaste, and up to 0.465% in mouthwash. This safety evaluation only applies to the hydroxyapatite (nano) with the following characteristics: - compo

Expert Verdict

Nano-Hydroxyapatite is generally considered safe for use as an abrasive, bulking agent, skin conditioning agent, and oral care agent in cosmetic products.

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Concern Level: Low

Frequently Asked Questions

Is Nano-Hydroxyapatite safe in cosmetics?

Nano-Hydroxyapatite is generally considered safe for use as an abrasive, bulking agent, skin conditioning agent, and oral care agent in cosmetic products. The EU classifies Nano-Hydroxyapatite as "permitted". Safety rating: GOOD. This ingredient has been reviewed by sccs.

Is Nano-Hydroxyapatite allowed in the EU?

Nano-Hydroxyapatite EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Nano-Hydroxyapatite do in cosmetics?

Nano-Hydroxyapatite functions as: abrasive, bulking agent, skin conditioning agent, and oral care agent in cosmetic products. It is classified as a Cosmetic Ingredient in our database. CAS number: 1306-06-5.

What is the Margin of Safety for Nano-Hydroxyapatite?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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