Nicotinyl Alcohol

INCI: NICOTINYL ALCOHOL

CAS Number
100-55-0
Function
Skin Conditioning (vasodilator — stimulates local blood circulation)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — not restricted under 21 CFR. Note: also has pharmaceutical monograph (USAN)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Vasodilator effect causing flushing and erythema; concentration-dependent tolerability with GHS irritant classification and incompatibility with oxidizing agents.

⚠️
Concern Level: Moderate

Frequently Asked Questions

Is Nicotinyl Alcohol safe in cosmetics?

Vasodilator effect causing flushing and erythema; concentration-dependent tolerability with GHS irritant classification and incompatibility with oxidizing agents. The EU classifies Nicotinyl Alcohol as "permitted". Safety rating: MODERATE.

Is Nicotinyl Alcohol allowed in the EU?

Nicotinyl Alcohol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Nicotinyl Alcohol do in cosmetics?

Nicotinyl Alcohol functions as: Skin Conditioning (vasodilator — stimulates local blood circulation). It is classified as a cosmetic ingredient in our database. CAS number: 100-55-0.

What is the Margin of Safety for Nicotinyl Alcohol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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