Excellent Emollient NOAEL Data

Octyldodecanol

INCI: OCTYLDODECANOL

CAS Number
5333-42-6
Function
emollient, solvent, skin-conditioning
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR: safe in cosmetics at present practices of use; branched fatty alcohol providing excellent spreading and co-solvent properties for pigment dispersion; reduces tackiness of polybutene-based gloss systems; no FDA restrictions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Octyldodecanol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOEL >=1 other oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH

Expert Verdict

Branched fatty alcohol providing spreading, co-solvent, and tack-reducing functions in lip gloss formulations with no regulatory restrictions and excellent safety profile at cosmetic concentrations.

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Concern Level: None

Regulatory Flags

cir-approved lip-safe fatty-alcohol spreading-agent pigment-dispersant lip-gloss tack-reducer oral-safe metabolizable ifra_fragrance

Frequently Asked Questions

Is Octyldodecanol safe in cosmetics?

Branched fatty alcohol providing spreading, co-solvent, and tack-reducing functions in lip gloss formulations with no regulatory restrictions and excellent safety profile at cosmetic concentrations. The EU classifies Octyldodecanol as "permitted". Safety rating: EXCELLENT. 2 toxicological study endpoint(s) are available in our database.

Is Octyldodecanol allowed in the EU?

Octyldodecanol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Octyldodecanol do in cosmetics?

Octyldodecanol functions as: emollient, solvent, skin-conditioning. It is classified as a Emollient in our database. CAS number: 5333-42-6.

What is the Margin of Safety for Octyldodecanol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Octyldodecanol?

The NOAEL (No Observed Adverse Effect Level) for Octyldodecanol is >=1 other based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

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