Ornithine

INCI: ORNITHINE

CAS Number
70-26-8
Function
Skin Conditioning, Collagen Stimulation, Skin Firming
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No specific FDA restrictions on ornithine as cosmetic ingredient. Listed in FDA substance registry (UNII: E524N2IXA3). Sold as dietary supplement under DSHEA.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Ornithine is permitted without EU restriction but lacks dedicated dermal safety dossier. L-ornithine monohydrochloride tested negative for genotoxicity with high NOAELs (3,445โ€“3,986 mg/kg/day) established in 90-day rat study.

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Concern Level: Low

Frequently Asked Questions

Is Ornithine safe in cosmetics?

Ornithine is permitted without EU restriction but lacks dedicated dermal safety dossier. L-ornithine monohydrochloride tested negative for genotoxicity with high NOAELs (3,445โ€“3,986 mg/kg/day) established in 90-day rat study. The EU classifies Ornithine as "permitted". Safety rating: GOOD.

Is Ornithine allowed in the EU?

Ornithine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ornithine do in cosmetics?

Ornithine functions as: Skin Conditioning, Collagen Stimulation, Skin Firming. It is classified as a Cosmetic Ingredient in our database. CAS number: 70-26-8.

What is the Margin of Safety for Ornithine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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