Palmitoyl Hexapeptide-12

INCI: PALMITOYL HEXAPEPTIDE-12

CAS Number
171263-26-6
Function
Signal peptide with palmitoyl lipidation for enhanced stratum corneum penetration. Stimulates extracellular matrix components. Used at very low active concentrations in W/W cream formulations.
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No specific FDA restrictions. No pre-market approval required under MoCRA.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Palmitoyl Hexapeptide-12 is a lipidated signal peptide used at very low concentrations (0.0004% active) in W/W cream formulations with no regulatory restrictions in EU or US markets.

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Concern Level: Low

Frequently Asked Questions

Is Palmitoyl Hexapeptide-12 safe in cosmetics?

Palmitoyl Hexapeptide-12 is a lipidated signal peptide used at very low concentrations (0.0004% active) in W/W cream formulations with no regulatory restrictions in EU or US markets. The EU classifies Palmitoyl Hexapeptide-12 as "permitted". Safety rating: GOOD.

Is Palmitoyl Hexapeptide-12 allowed in the EU?

Palmitoyl Hexapeptide-12 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Palmitoyl Hexapeptide-12 do in cosmetics?

Palmitoyl Hexapeptide-12 functions as: Signal peptide with palmitoyl lipidation for enhanced stratum corneum penetration. Stimulates extracellular matrix components. Used at very low active concentrations in W/W cream formulations.. It is classified as a Active Ingredient in our database. CAS number: 171263-26-6.

What is the Margin of Safety for Palmitoyl Hexapeptide-12?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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