Is Phenylethyl Resorcinol safe in cosmetics?
Phenylethyl Resorcinol has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Phenylethyl Resorcinol
INCI: PHENYLETHYL RESORCINOL
Phenylethyl Resorcinol (CAS 85-27-8) is a cosmetic cosmetic ingredient functioning as Tyrosinase inhibitor; TRP-1 inhibitor; melanogenesis inhibitor. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 85-27-8 →
Auto-generated CPSR Part A draft with source citations
Function
Tyrosinase inhibitor; TRP-1 inhibitor; melanogenesis inhibitor
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted cosmetic ingredient. No specific FDA restriction. Not listed in OTC drug monographs. Cosmetic brightening claims acceptable. Patent-protected by Symrise.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Phenylethyl Resorcinol.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Phenylethyl Resorcinol.
Regulatory Flags
eu-unrestricted
us-permitted
symrise-patented-symwhite-377
tyrosinase-inhibitor
trp-1-inhibitor
22x-more-potent-than-kojic-acid-in-vitro
oil-soluble
chemically-stable
low-concentration-active-0.1-0.5pct
no-oxidation-instability
no-dedicated-mos
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3961037
Frequently Asked Questions
Is Phenylethyl Resorcinol allowed in the EU?
Phenylethyl Resorcinol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phenylethyl Resorcinol do in cosmetics?
Phenylethyl Resorcinol functions as: Tyrosinase inhibitor; TRP-1 inhibitor; melanogenesis inhibitor. It is classified as a cosmetic ingredient in our database. CAS number: 85-27-8.
Is Phenylethyl Resorcinol used outside cosmetics?
Phenylethyl Resorcinol also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Phenylethyl Resorcinol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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