Pichia r-sh-Polypeptide-19 Ferment Extract Filtrate

INCI: PICHIA R-SH-POLYPEPTIDE-19 FERMENT EXTRACT FILTRATE

CAS Number
Not assigned
Function
Skin conditioning, emollient, skin protecting
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not specifically listed by FDA; same general provisions as Polypeptide-1

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Recombinant/GMO-derived ingredient with identical regulatory concerns as Polypeptide-1. The Polypeptide-19 designation indicates a different peptide sequence, but both use the same Pichia pastoris recombinant expression platform. No CIR, SCCS, or published peer-reviewed safety data found. Full supplier-provided safety dossier including peptide characterization, impurity profiling, stability data, and dermal sensitization testing is mandatory for CPSR support.

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Concern Level: High

Regulatory Flags

plant-extract potential-allergen

Frequently Asked Questions

Is Pichia r-sh-Polypeptide-19 Ferment Extract Filtrate safe in cosmetics?

Recombinant/GMO-derived ingredient with identical regulatory concerns as Polypeptide-1. The Polypeptide-19 designation indicates a different peptide sequence, but both use the same Pichia pastoris recombinant expression platform. No CIR, SCCS, or published peer-reviewed safety data found. Full supplier-provided safety dossier including peptide characterization, impurity profiling, stability data, and dermal sensitization testing is mandatory for CPSR support. The EU classifies Pichia r-sh-Polypeptide-19 Ferment Extract Filtrate as "permitted". Safety rating: POOR.

Is Pichia r-sh-Polypeptide-19 Ferment Extract Filtrate allowed in the EU?

Pichia r-sh-Polypeptide-19 Ferment Extract Filtrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Pichia r-sh-Polypeptide-19 Ferment Extract Filtrate do in cosmetics?

Pichia r-sh-Polypeptide-19 Ferment Extract Filtrate functions as: Skin conditioning, emollient, skin protecting. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned.

What is the Margin of Safety for Pichia r-sh-Polypeptide-19 Ferment Extract Filtrate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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