Podophyllum Peltatum Rhizome/Root Extract

INCI: PODOPHYLLUM PELTATUM RHIZOME/ROOT EXTRACT

CAS Number
90063-90-4
Function
Skin conditioning
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Podophyllotoxin is a prescription drug ingredient (FDA); not GRAS for cosmetics; no CIR monograph

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

CMR substance with antimitotic, embryotoxic, and genotoxic properties causing severe skin irritation. Used medically only as a prescription topical for warts under medical supervision.

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Concern Level: High

Regulatory Flags

plant-extract

Frequently Asked Questions

Is Podophyllum Peltatum Rhizome/Root Extract safe in cosmetics?

CMR substance with antimitotic, embryotoxic, and genotoxic properties causing severe skin irritation. Used medically only as a prescription topical for warts under medical supervision. The EU classifies Podophyllum Peltatum Rhizome/Root Extract as "prohibited". Safety rating: POOR.

Is Podophyllum Peltatum Rhizome/Root Extract allowed in the EU?

Podophyllum Peltatum Rhizome/Root Extract EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Podophyllum Peltatum Rhizome/Root Extract do in cosmetics?

Podophyllum Peltatum Rhizome/Root Extract functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 90063-90-4.

What is the Margin of Safety for Podophyllum Peltatum Rhizome/Root Extract?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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