Serine

INCI: SERINE [^1_13]

CAS Number
56-45-1 (L-Serine) [^1_12][^1_13]
Function
Skin conditioning, hair conditioning, antistatic, NMF component, humectant [^1_12][^1_14]
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; CIR assessed ฮฑ-amino acids (including serine) as safe as used in cosmetics [^1_13]

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

None significant โ€” endogenous compound, well-characterized safety profile [^1_14][^1_13]

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Concern Level: None

Frequently Asked Questions

Is Serine safe in cosmetics?

None significant โ€” endogenous compound, well-characterized safety profile [^1_14][^1_13] The EU classifies Serine as "permitted". Safety rating: EXCELLENT.

Is Serine allowed in the EU?

Serine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Serine do in cosmetics?

Serine functions as: Skin conditioning, hair conditioning, antistatic, NMF component, humectant [^1_12][^1_14]. It is classified as a cosmetic ingredient in our database. CAS number: 56-45-1 (L-Serine) [^1_12][^1_13].

What is the Margin of Safety for Serine?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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