Is Serine safe in cosmetics?
Serine has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
EXCELLENT
Cosmetic Ingredient
Serine
INCI: SERINE [^1_13]
Serine (CAS 56-45-1 (L-Serine) [^1_12][^1_13]) is a cosmetic cosmetic ingredient functioning as Skin conditioning, hair conditioning, antistatic, NMF component, humectant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 56-45-1 (L-Serine) [^1_12][^1_13] →
Function
Skin conditioning, hair conditioning, antistatic, NMF component, humectant [^1_12][^1_14]
Editorial assessment
EXCELLENT
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; CIR assessed α-amino acids (including serine) as safe as used in cosmetics [^1_13]
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Serine.
Calculate MoS for your specific formulation with the MoS Calculator.
Editorial summary
Preliminary editorial summary for Serine — not a computed safety verdict. See the sourced toxicological data above.
Frequently Asked Questions
Is Serine allowed in the EU?
Serine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Serine do in cosmetics?
Serine functions as: Skin conditioning, hair conditioning, antistatic, NMF component, humectant [^1_12][^1_14]. It is classified as a cosmetic ingredient in our database. CAS number: 56-45-1 (L-Serine) [^1_12][^1_13].
Compliance Tools
Check Serine compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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