Moderate Antioxidant

Sesamol

INCI: SESAMOL

CAS Number
533-31-3
Function
Antioxidant, Skin Lightening, Photoprotective, Anti-Aging
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR assessed Sesamum Indicum Seed Oil and related derivatives as safe, but no standalone CIR final report on isolated sesamol.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Sesamol demonstrates strong antioxidant and anti-melanogenic activity but carries GHS Category 4 acute oral toxicity classification and has critical data gaps including no dermal absorption study and no 90-day repeated dose dermal study.

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Concern Level: Moderate

Regulatory Flags

eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is Sesamol safe in cosmetics?

Sesamol demonstrates strong antioxidant and anti-melanogenic activity but carries GHS Category 4 acute oral toxicity classification and has critical data gaps including no dermal absorption study and no 90-day repeated dose dermal study. The EU classifies Sesamol as "permitted". Safety rating: MODERATE.

Is Sesamol allowed in the EU?

Sesamol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Sesamol do in cosmetics?

Sesamol functions as: Antioxidant, Skin Lightening, Photoprotective, Anti-Aging. It is classified as a Antioxidant in our database. CAS number: 533-31-3.

What is the Margin of Safety for Sesamol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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