Is Sodium Acetylated Hyaluronate safe in cosmetics?
Sodium Acetylated Hyaluronate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Sodium Acetylated Hyaluronate
INCI: SODIUM ACETYLATED HYALURONATE
Sodium Acetylated Hyaluronate (CAS 1260786-40-0) is a cosmetic humectant functioning as Humectant, skin-conditioning, film-forming. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 1260786-40-0 →
Auto-generated CPSR Part A draft with source citations
Function
Humectant, skin-conditioning, film-forming
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted under FDCA as a cosmetic ingredient with no pre-market approval required. CIR Expert Panel final report (June 2023) concludes safe in cosmetics at present practices and concentrations (up to 0.1%). FDA VCRP 2023 data: 455 formulations reported (414 leave-on, 41 rinse-off). Not classified as GRAS (not a food/drug active).
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Acetylated Hyaluronate.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Sodium Acetylated Hyaluronate, relevant to systemic exposure and MoS calculations.
Absorption %
6-12%
Penetration Level
epidermis
Penetration Depth
epidermis
Molecular Weight
Variable Da
Log P
-9.5
Systemic Absorption
minimal
Topical Bioavailability
4-10%
Safety Margin Factor
low
Vehicle Dependent
Yes — absorption varies by formulation
Source: Carbohydr Polym 2018
Additional Ingredient Properties
8 property records from structured ingredient metadata.
acne
{"anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0-1", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_acne": "No restriction", …
biopolymer
{"cas_number": "not_assigned", "polymer_class": "hyaluronic_acid", "botanical_source": "HA with increased acetylation", "molecular_weight_range_kDa": "50-1500", "monosaccharide_composition": "acetylated glucuronic acid/N-acetylglucosamine", "degree_of_branching": "linear", "charge_type": "anionic", "viscosity_1pct_solution_mPas": "1000-8000", "pseudoplastic_behavior": "moderate", "thixotropy": "we…
concentration
{"min_concentration_pct": "0.1", "max_concentration_pct": "1.0", "typical_concentration_pct": "0.5", "product_type": "Serum", "function_at_concentration": "Enhanced penetration, hydration", "source": "Supplier TDS (Bloomage)"}
dermal_absorption
{"molecular_weight_da": "Variable", "log_p_value": "-9.5", "skin_penetration_level": "epidermis", "penetration_depth": "epidermis", "absorption_pct": "6-12", "systemic_absorption": "minimal", "penetration_enhancer": "yes", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "strengthens", "bioavailability_topical_pct": "4-10", "safety_margin_factor": "low", "source": "Carb…
humectant
{"cas_number": "variable", "ingredient_class": "humectant/glycosaminoglycan", "molecular_weight_Da": "variable", "chemical_type": "polysaccharide", "water_binding_mechanism": "hydrogen_bonding/hygroscopic/film_forming", "water_holding_capacity_g_per_g": "8.0-15.0", "hygroscopicity_at_50_RH": "excellent", "hygroscopicity_at_80_RH": "excellent", "NMF_component": "no", "NMF_percentage_natural": "0", …
solubility_hlb
{"water_soluble": "yes", "oil_soluble": "no", "soluble_in": "water, glycerin", "insoluble_in": "oils, ethanol, silicones, propylene glycol", "log_p": "-5.2", "appearance": "white powder", "source": "Bloomage"}
synergy
{"inci_name_2": "Hyaluronic Acid", "synergy_type": "moisturizing-synergy", "synergy_description": "Lipophilic HA derivative with standard HA for enhanced adhesion", "combined_benefit": "Superior skin adhesion, longer-lasting hydration, improved barrier interaction", "efficacy_multiplier": "2.2x", "mechanism_of_action": "Acetylated form adheres better to skin lipids; standard HA provides classic hy…
uv_stability
{"uv_stable": "yes", "uv_degradation_rate": "stable", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "no", "color_change_uv": "no", "odor_change_uv": "no", "efficacy_loss_uv_pct": "0", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_under_uv": …
Expert Verdict
Expert safety assessment and concern-level summary for Sodium Acetylated Hyaluronate.
Regulatory Flags
eu-unrestricted
no-sccs-opinion
cir-approved
humectant
non-sensitizing
Frequently Asked Questions
Is Sodium Acetylated Hyaluronate allowed in the EU?
Sodium Acetylated Hyaluronate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Acetylated Hyaluronate do in cosmetics?
Sodium Acetylated Hyaluronate functions as: Humectant, skin-conditioning, film-forming. It is classified as a Humectant in our database. CAS number: 1260786-40-0.
Compliance Tools
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Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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