Excellent Humectant Dermal Penetration

Sodium Acetylated Hyaluronate

INCI: SODIUM ACETYLATED HYALURONATE

CAS Number
1260786-40-0
Function
Humectant, skin-conditioning, film-forming
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted under FDCA as a cosmetic ingredient with no pre-market approval required. CIR Expert Panel final report (June 2023) concludes safe in cosmetics at present practices and concentrations (up to 0.1%). FDA VCRP 2023 data: 455 formulations reported (414 leave-on, 41 rinse-off). Not classified as GRAS (not a food/drug active).

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Dermal Penetration Profile

Skin absorption and penetration characteristics of Sodium Acetylated Hyaluronate, relevant to systemic exposure and MoS calculations.

Absorption %
6-12%
Penetration Level
epidermis
Penetration Depth
epidermis
Molecular Weight
Variable Da
Log P
-9.5
Systemic Absorption
minimal
Topical Bioavailability
4-10%
Safety Margin Factor
low
Vehicle Dependent
Yes โ€” absorption varies by formulation

Source: Carbohydr Polym 2018

Expert Verdict

Sodium Acetylated Hyaluronate is an acetylated ester derivative of hyaluronic acid functioning as a humectant in cosmetics at 0.01-0.1%, unrestricted under EU Regulation (EC) No. 1223/2009 with no listing in Annexes II-VI, and concluded safe by the CIR Expert Panel (June 2023) based on negative genotoxicity, no sensitization in HRIPT testing of 104 subjects, non-irritating profile, and negligible systemic absorption.

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Concern Level: None

Regulatory Flags

eu-unrestricted no-sccs-opinion cir-approved humectant non-sensitizing

Frequently Asked Questions

Is Sodium Acetylated Hyaluronate safe in cosmetics?

Sodium Acetylated Hyaluronate is an acetylated ester derivative of hyaluronic acid functioning as a humectant in cosmetics at 0.01-0.1%, unrestricted under EU Regulation (EC) No. 1223/2009 with no listing in Annexes II-VI, and concluded safe by the CIR Expert Panel (June 2023) based on negative genotoxicity, no sensitization in HRIPT testing of 104 subjects, non-irritating profile, and negligible systemic absorption. The EU classifies Sodium Acetylated Hyaluronate as "permitted". Safety rating: EXCELLENT.

Is Sodium Acetylated Hyaluronate allowed in the EU?

Sodium Acetylated Hyaluronate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Sodium Acetylated Hyaluronate do in cosmetics?

Sodium Acetylated Hyaluronate functions as: Humectant, skin-conditioning, film-forming. It is classified as a Humectant in our database. CAS number: 1260786-40-0.

What is the Margin of Safety for Sodium Acetylated Hyaluronate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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