Sphingomyelin

INCI: SPHINGOMYELIN

CAS Number
85187-10-6
Function
Skin conditioning, emollient; major component of cell membrane lipid bilayer; supports barrier function
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; CIR assessed within the ceramide family as "safe as used"; also reviewed within the lecithin/phospholipid safety assessment

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

If animal-derived (e.g., bovine or egg), BSE/TSE sourcing restrictions apply (no bovine CNS tissue per 21 CFR 700.27); egg-derived sphingomyelin may trigger allergen labeling requirements in some jurisdictions; plant-derived or synthetic alternatives available

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Concern Level: Low

Regulatory Flags

potential-allergen natural-origin

Frequently Asked Questions

Is Sphingomyelin safe in cosmetics?

If animal-derived (e.g., bovine or egg), BSE/TSE sourcing restrictions apply (no bovine CNS tissue per 21 CFR 700.27); egg-derived sphingomyelin may trigger allergen labeling requirements in some jurisdictions; plant-derived or synthetic alternatives available The EU classifies Sphingomyelin as "permitted". Safety rating: EXCELLENT.

Is Sphingomyelin allowed in the EU?

Sphingomyelin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Sphingomyelin do in cosmetics?

Sphingomyelin functions as: Skin conditioning, emollient; major component of cell membrane lipid bilayer; supports barrier function. It is classified as a cosmetic ingredient in our database. CAS number: 85187-10-6.

What is the Margin of Safety for Sphingomyelin?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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