Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
🚫 DO NOT USE IN COSMETICS. Annex II prohibited substance in EU. Anti-androgenic hormonal activity poses endocrine disruption risk. Any product containing this would be non-compliant under EC 1223/2009 and would likely trigger FDA drug classification in the US.
Regulatory Flags
Frequently Asked Questions
Is Spironolactone safe in cosmetics?
🚫 DO NOT USE IN COSMETICS. Annex II prohibited substance in EU. Anti-androgenic hormonal activity poses endocrine disruption risk. Any product containing this would be non-compliant under EC 1223/2009 and would likely trigger FDA drug classification in the US. The EU classifies Spironolactone as "prohibited". Safety rating: POOR.
Is Spironolactone allowed in the EU?
Spironolactone EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Spironolactone do in cosmetics?
Spironolactone functions as: Anti-androgen (pharmaceutical); historically explored for anti-acne topical use. It is classified as a cosmetic ingredient in our database. CAS number: 52-01-7.
What is the Margin of Safety for Spironolactone?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check Spironolactone compliance across multiple jurisdictions:
Related Ingredients
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