Is Strontium Chloride safe in cosmetics?
Strontium Chloride has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Strontium Chloride
Also known as: Strontium(II) chloride, Strontium chloride (SrCl2), EINECS 233-971-6, UNII-EKE8PS9J6Z, SrCl2
INCI: STRONTIUM CHLORIDE
Strontium Chloride (CAS 10476-85-4) is a cosmetic active ingredient functioning as Antipruritic, Anti-irritant, Sensory Modulator. Reported NOAEL =12.4 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 10476-85-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Strontium Chloride is classified GHS Danger (H315, H318, H335, H341) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antipruritic, Anti-irritant, Sensory Modulator
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
strontium dichloride
InChIKey
AHBGXTDRMVNFER-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; no US concentration cap for cosmetic use. Has been used in OTC desensitizing toothpastes (strontium acetate, related compound) and sensitive-skin creams.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Strontium Chloride.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Strontium Chloride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =12.4 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =225 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =525 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: (a) Oral products (b) Shampoo and face products. Max: (a) 3.5% (as strontium) When mixed with other permitted strontium products the total strontium content must not exceed 3.5% (b) 2.1% (as strontium) When mixed with other permitted strontium products the total strontium content must not exceed 2.1%.
BRIN Brazil/India Cosmetics
India: Restricted · max (a) 3.5% (as strontium) When mixed with other permitted strontium products the total strontium content must not exceed 3.5% (b) 2.1% (as strontium) When mixed with other permitted strontium products the total strontium content must not exceed 2.1%
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | restricted | 3.5 | Sensitive skin products |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Strontium Chloride.
Regulatory Flags
active
neurogenic-modulator
anti-itch
sensory-suppressor
reactive-skin
sensitive-skin
mineral
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Strontium Chloride by CAS number or substance name.
Studies
3
Lowest NOAEL
12.4 mg/kg bw/day
Highest NOAEL
525 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Strontium(II) chloride
Strontium chloride (SrCl2)
EINECS 233-971-6
UNII-EKE8PS9J6Z
SrCl2
Chemical Function
Softener and conditioner
Humectant
Regulatory Lists
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
STRONTIUM CHLORIDE
ChEMBL ID
CHEMBL2219640
Max Phase
4
Adverse Event Associations
42
Frequently Asked Questions
Is Strontium Chloride allowed in the EU?
Strontium Chloride EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Strontium Chloride do in cosmetics?
Strontium Chloride functions as: Antipruritic, Anti-irritant, Sensory Modulator. It is classified as a Active Ingredient in our database. CAS number: 10476-85-4.
What is the NOAEL for Strontium Chloride?
The NOAEL (No Observed Adverse Effect Level) for Strontium Chloride is =12.4 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Strontium Chloride used outside cosmetics?
Strontium Chloride also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Strontium Chloride have different safety status in cosmetics vs industrial chemicals?
Strontium Chloride is classified GHS Danger (H315, H318, H335, H341) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Strontium Chloride compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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