Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for Disodium Phosphate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 4590 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 10000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 4345 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 4590 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Safe as used in cosmetics when formulated to be nonirritating. CIR Expert Panel (2021) concluded safe at concentrations up to 2.9%. FDA GRAS for food; no prohibited or restricted status under EU Cosmetics Regulation 1223/2009.
Regulatory Flags
Frequently Asked Questions
Is Disodium Phosphate safe in cosmetics?
Safe as used in cosmetics when formulated to be nonirritating. CIR Expert Panel (2021) concluded safe at concentrations up to 2.9%. FDA GRAS for food; no prohibited or restricted status under EU Cosmetics Regulation 1223/2009. The EU classifies Disodium Phosphate as "permitted". Safety rating: EXCELLENT. 6 toxicological study endpoint(s) are available in our database.
Is Disodium Phosphate allowed in the EU?
Disodium Phosphate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Disodium Phosphate do in cosmetics?
Disodium Phosphate functions as: Buffering agent, pH adjuster, corrosion inhibitor. It is classified as a cosmetic ingredient in our database. CAS number: 7558-79-4.
What is the Margin of Safety for Disodium Phosphate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Disodium Phosphate?
The NOAEL (No Observed Adverse Effect Level) for Disodium Phosphate is 4590 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 6 study endpoints are available. Source: COSMOS_DB.
Is Disodium Phosphate classified as hazardous under GHS?
Disodium Phosphate carries a GHS signal word of "WARNING". Hazard statements: Causes mild skin irritation Causes eye irritation. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
Check Disodium Phosphate compliance across multiple jurisdictions:
Related Ingredients
Is Disodium Phosphate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Disodium Phosphate in your formulation.