Is Sucrose safe in cosmetics?
Sucrose has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Sucrose
Also known as: alpha-D-Glucopyranoside, beta-D-fructofuranosyl, D(+)-Sucrose, alpha-D-Glucopyranoside, beta-D-fructofuranosyl-, .alpha.-D-Glucopyranoside, .beta.-D-fructofuranosyl, Amerfand (+15 more)
INCI: SUCROSE
Sucrose (CAS 57-50-1) is a cosmetic cosmetic ingredient functioning as Humectant, skin conditioning agent, flavoring agent, bulking agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 57-50-1 →
Auto-generated CPSR Part A draft with source citations
Function
Humectant, skin conditioning agent, flavoring agent, bulking agent
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
InChIKey
CZMRCDWAGMRECN-UGDNZRGBSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
GRAS (Generally Recognized As Safe); permitted in food and cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sucrose.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
May cause mechanical irritation.
Long-term Exposure Effects
The substance may have effects on the teeth. This may result in dental caries. Repeated or prolonged contact with skin may cause dermatitis.
Routes of Exposure
The substance can be absorbed into the body by inhalation and by ingestion.
EPA ToxValDB — Toxicity Values
2 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| NOEL | =6000 ppm | Rat | oral | acute | ECOTOX |
| LD50 | =29700 mg/kg | Rat | oral | - | ChemIDplus |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Roberts Skin Permeation (Mendeley 2022)
MW: 342.3
Log Kow: -3.85
Log Kp: -5.026872146400302
Log Jmax: -7.063084319054746
Source: Roberts_Cheruvu_Mendeley_2022
Additional Ingredient Properties
2 property records from structured ingredient metadata.
humectant
{"cas_number": "57-50-1", "ingredient_class": "humectant/sugar_derivative", "molecular_weight_Da": "342.30", "chemical_type": "polysaccharide", "water_binding_mechanism": "hydrogen_bonding/hygroscopic", "water_holding_capacity_g_per_g": "0.4-0.6", "hygroscopicity_at_50_RH": "good", "hygroscopicity_at_80_RH": "excellent", "NMF_component": "no", "NMF_percentage_natural": "0", "TEWL_reduction_pct": "…
pediatric_safety
{"safe_for_newborn_0_6m": "yes", "safe_for_infant_6_12m": "yes", "safe_for_toddler_1_3y": "yes", "safe_for_child_3_12y": "yes", "safe_for_teen_12_18y": "yes", "pediatric_max_concentration_pct": "10.0", "adult_max_concentration_pct": "10.0", "pediatric_dermal_absorption_factor": "normal", "oral_ingestion_risk": "low", "diaper_area_safe": "yes", "pediatric_allergy_prevalence": "low", "banned_in_chil…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Evidence for Carcinogenicity
A4: Not classifiable as a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
ICSC Safety Card
1507
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Binder
Flavouring and nutrient
Fragrance
Humectant
Processing aids not otherwise specified
Softener and conditioner
Regulatory List Membership (4)
EU Restricted for Children (Cosmetics)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Sucrose.
Regulatory Flags
endocrine_disruptor
eu_children_restricted
epa_safer_alternative
ifra_fragrance
fda_food_additive
Known Synonyms
alpha-D-Glucopyranoside, beta-D-fructofuranosyl
D(+)-Sucrose
alpha-D-Glucopyranoside, beta-D-fructofuranosyl-
.alpha.-D-Glucopyranoside, .beta.-D-fructofuranosyl
Amerfand
EINECS 200-334-9
Fructofuranoside, alpha-D-glucopyranosyl, beta-D
beta-D-Fructofuranosyl alpha-D-glucopyranoside
Glucopyranoside, beta-D-fructofuranosyl, alpha-D
alpha-D-Glucopyranosyl beta-D-fructofuranoside
(alpha-D-Glucosido)-beta-D-fructofuranoside
NCI-C56597
Rohrzucker
Sucraloxum
UNII-C151H8M554
(2R,3R,4S,5R,6R)-2-[(2S,3S,4R,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
(2R,3R,4S,5R,6R)-2-[(2S,3S,4R,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)tetrahydrofuran-2-yl]oxy-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
(2R,3R,4S,5R,6R)-2-[(2S,3S,4R,5R)-3,4-dihydroxy-2,5-dimethylol-tetrahydrofuran-2-yl]oxy-6-methylol-tetrahydropyran-3,4,5-triol
(2R,3R,4S,5S,6R)-2-{[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol
Sacharose
Chemical Function
Humectant
Softener and conditioner
Binder
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
pharmaceutical
active_ingredient; Europe; Pesticides
active_ingredient; Australia
inert_ingredient; non_food_use; Pesticides
children; Europe; Personal care
children; Europe; Personal care - specialized bath products - bath salts
animal_products
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
Canada; pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe
Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; Europe
fracking; water
active_ingredient; Pesticides
active_ingredient; Pesticides
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
SUCROSE
ChEMBL ID
CHEMBL253582
Max Phase
3
Adverse Event Associations
366
Frequently Asked Questions
Is Sucrose allowed in the EU?
Sucrose EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sucrose do in cosmetics?
Sucrose functions as: Humectant, skin conditioning agent, flavoring agent, bulking agent. It is classified as a cosmetic ingredient in our database. CAS number: 57-50-1.
Is Sucrose used outside cosmetics?
Sucrose also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Sucrose compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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