Is Synephrine safe in cosmetics?
Synephrine has a safety rating of "MODERATE" in our database. EU status: restricted. US status: restricted.
Moderate
Cosmetic Ingredient
Synephrine
Also known as: RS)-1-(4-Hydroxyphenyl)-2-(methylamino)ethanol, 4-(1-Hydroxy-2-(methylamino)ethyl)phenol, Benzenemethanol, 4-hydroxy-alpha-((methylamino)methyl)-, Benzyl alcohol, p-hydroxy-alpha-((methylamino)methyl)-, Analeptin (+15 more)
INCI: SYNEPHRINE
Synephrine (CAS 94-07-5) is a cosmetic cosmetic ingredient functioning as Skin Protecting. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 94-07-5 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Protecting
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
4-[1-hydroxy-2-(methylamino)ethyl]phenol
InChIKey
YRCWQPVGYLYSOX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
restricted
US Notes
Not specifically restricted for cosmetic use; generally permitted under manufacturer's safety substantiation responsibility
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Synephrine.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Expert Verdict
Expert safety assessment and concern-level summary for Synephrine.
Regulatory Flags
potential-allergen
Known Synonyms
RS)-1-(4-Hydroxyphenyl)-2-(methylamino)ethanol
4-(1-Hydroxy-2-(methylamino)ethyl)phenol
Benzenemethanol, 4-hydroxy-alpha-((methylamino)methyl)-
Benzyl alcohol, p-hydroxy-alpha-((methylamino)methyl)-
Analeptin
EINECS 202-300-9
Ethaphene
4-Hydroxy-alpha-((methylamino)methyl)benzenemethanol
p-Hydroxy-alpha-((methylamino)methyl)benzyl alcohol
p-Hydroxyphenylmethylaminoethanol
1-(4-Hydroxyphenyl)-N-methylethanolamine
p-Methylaminoethanolphenol
beta-Methylamino-alpha-(4-hydroxyphenyl)ethyl alcohol
Methylaminomethyl(4-hydroxyphenyl)carbinol
NSC 166285
p-Oxedrine
Parasympatol
Simpalon
Simpatol
Sympaethamine
Chemical Function
Humectant
Regulatory Lists
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
OXEDRINE
ChEMBL ID
CHEMBL33720
Max Phase
-1
Frequently Asked Questions
Is Synephrine allowed in the EU?
Synephrine EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Synephrine do in cosmetics?
Synephrine functions as: Skin Protecting. It is classified as a cosmetic ingredient in our database. CAS number: 94-07-5.
Is Synephrine used outside cosmetics?
Synephrine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Synephrine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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