Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Tetrahydrolinalool. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 5000 ppm | oral | rat | oral | REACH |
| NOAEL | 250 mg/kg bw/day | dermal | rat | dermal | REACH |
| NOAEL | 160 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 200 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Weak sensitizer in LLNA; IFRA restricted; very stable in formulations; widely used benchmark for read-across to related terpene alcohols
Regulatory Flags
Frequently Asked Questions
Is Tetrahydrolinalool safe in cosmetics?
Weak sensitizer in LLNA; IFRA restricted; very stable in formulations; widely used benchmark for read-across to related terpene alcohols The EU classifies Tetrahydrolinalool as "restricted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database.
Is Tetrahydrolinalool allowed in the EU?
Tetrahydrolinalool EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrahydrolinalool do in cosmetics?
Tetrahydrolinalool functions as: Fragrance Ingredient (floral, fresh, citrus profile). It is classified as a cosmetic ingredient in our database. CAS number: 78-69-3.
What is the Margin of Safety for Tetrahydrolinalool?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Tetrahydrolinalool?
The NOAEL (No Observed Adverse Effect Level) for Tetrahydrolinalool is 5000 ppm based on a oral study via oral route in rat. A total of 4 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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