Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Theobroma Cacao Seed Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 4280 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2140 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
Expert Verdict
Permitted in EU (not listed in Annexes II-VI of Regulation (EC) No 1223/2009; no concentration restrictions). Not restricted by FDA under MoCRA. CIR reviewed cocoa seed butter and constituent methylxanthines separately, concluding caffeine and theobromine are safe in cosmetics at present use levels. No dedicated CIR monograph for the seed extract itself.
Regulatory Flags
Frequently Asked Questions
Is Theobroma Cacao Seed Extract safe in cosmetics?
Permitted in EU (not listed in Annexes II-VI of Regulation (EC) No 1223/2009; no concentration restrictions). Not restricted by FDA under MoCRA. CIR reviewed cocoa seed butter and constituent methylxanthines separately, concluding caffeine and theobromine are safe in cosmetics at present use levels. No dedicated CIR monograph for the seed extract itself. The EU classifies Theobroma Cacao Seed Extract as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.
Is Theobroma Cacao Seed Extract allowed in the EU?
Theobroma Cacao Seed Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Theobroma Cacao Seed Extract do in cosmetics?
Theobroma Cacao Seed Extract functions as: Antioxidant, Skin Conditioning. It is classified as a Active Ingredient in our database. CAS number: 84649-99-0.
What is the Margin of Safety for Theobroma Cacao Seed Extract?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Theobroma Cacao Seed Extract?
The NOAEL (No Observed Adverse Effect Level) for Theobroma Cacao Seed Extract is 4280 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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