Good Cosmetic Ingredient Sensitization Data

Thymol

Also known as: Caswell No. 856A, m-Cresol, 6-isopropyl-, p-Cymene, 3-hydroxy-, Cymophenol, alpha-, EINECS 201-944-8 (+15 more)

INCI: THYMOL

Thymol (CAS 89-83-8) is a cosmetic cosmetic ingredient functioning as Thymol is assigned two official CosIng functions. NOAEL 61.55 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.

View industrial chemical safety profile for CAS 89-83-8 →

Auto-generated CPSR Part A draft with source citations

Cross-Vertical Regulatory Divergence

Thymol is classified GHS Danger (H302, H314, H318, H411, H401) in the chemicals database but is allowed in EU cosmetics.

Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

CAS Number

89-83-8

View industrial chemical safety profile →

Function

Thymol is assigned two official CosIng functions

Safety Rating

GOOD

Chemistry & Identifiers

Formula

C10H14O

150.22 g/mol

EC Number

201-944-8

PubChem CID

6989

IUPAC Name

5-methyl-2-propan-2-ylphenol

InChIKey

MGSRCZKZVOBKFT-UHFFFAOYSA-N

ChEBI: CHEBI:27607 UNII: 3J50XA376E Wikidata: Q408883

Regulatory Status

EU EU Status permitted

US US Status permitted

US Notes No specific restrictions

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Thymol.

Calculate MoS for your specific formulation with the MoS Calculator.

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for Thymol across SCCS product categories, with measured dermal absorption where available.

Sensitization Profile

Contact sensitization data for Thymol based on clinical patch test studies and IFRA standards.

Sensitization Rate

low

Allergen Class

fragrance

EU Allergen Listed

Patch Test Positive Rate

0.2%

Cross-reactivity Group

none

Reaction Type

contact-dermatitis

Source: IVDK; literature review

EPA ToxValDB — Toxicity Values

6 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).

Endpoint	Value	Species	Route	Duration	Source
LD50	=980 mg/kg	Rat	oral	-	EFSA
LOEL	=0.1 mmol	Rat	injection	acute	ECOTOX
NOEL	=0.25 mmol	Rat	injection	acute	ECOTOX
LD50	=880 mg/kg	Guinea Pig	oral	-	ChemIDplus
LD50	=640 mg/kg	Mouse	oral	-	ChemIDplus
LD50	=980 mg/kg	Rat	oral	-	ChemIDplus

EU CLP Annex VI Harmonized Classification

Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.

Signal Word

Danger

Pictograms

Harmful / IrritantCorrosiveEnvironmental Hazard

Hazard Class and Category

Acute Tox. 4 *; Skin Corr. 1B; Aquatic Chronic 2

Hazard Statements

H302 Harmful if swallowed
H314 Causes severe skin burns and eye damage
H411 Toxic to aquatic life with long lasting effects

Inserted via ATP: CLP00

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type

Full

Tonnage Band

1,000 - 10,000 tonnes

Substance Type

SUBSTANCE

SVHC Candidate

Hazard classification: Restricted (Annex XVII)

Expanded Jurisdictional Detail

Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.

JPKR Japan/Korea Cosmetics

Japan (Positive (Preservative)): max 0.050

Japan (Restricted): max Wash-away: 0.050% | Leave-on: 0.050% | Mucosa: No limit (oral only)

Additional Jurisdictional Restrictions (2)

Jurisdiction	Status	Max %	Product Type
JP	restricted	Wash-away: 0.050% \| Leave-on: 0.050% \| Mucosa: No limit (oral only)	Wash-away: 0.050% \| Leave-on: 0.050% \| Mucosa: No limit (oral only)
CN	permitted_preservative	0.1	Oral care products

Expanded Dermal Absorption Data

Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.

Roberts Skin Permeation (Mendeley 2022)

MW: 150.2

Log Kow: 3.28

Log Kp: -1.2760748027008275

Log Jmax: -6.45

Source: Roberts_Cheruvu_Mendeley_2022

Additional Ingredient Properties

5 property records from structured ingredient metadata.

acne

{"cas_number": "89-83-8", "anti_acne_mechanism": "antibacterial", "comedogenicity_rating_0_to_5": "1", "acne_type_efficacy": "inflammatory", "p_acnes_mic_ug_per_ml": "100-500", "sebum_reduction_pct_clinical": "5-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "Max 1%", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "N…

allergen_detail

{"eu_allergen_listed": "no", "allergen_class": "fragrance", "patch_test_frequency_pct": "0.2", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "IVDK; literature review"}

deodorant

{"cas_number": "89-83-8", "ingredient_class": "antimicrobial_deodorant", "mechanism_of_action": "bacterial_growth_inhibition", "antiperspirant_efficacy_sweat_reduction_pct": "0", "deodorant_efficacy_hours": "8-12", "odor_reduction_pct": "50-70", "bacteriostatic": "yes", "bactericidal": "yes", "target_bacteria": "broad_spectrum", "microbiome_impact": "broad", "axillary_microbiome_effect": "varies b…

fragrance_ifra

{"cas_number": "89-83-8", "ifra_amendment_number": "49", "ifra_restriction_type": "Restricted", "ifra_max_use_level_category_1_pct": "0.038", "ifra_max_use_level_category_4_pct": "0.22", "ifra_max_use_level_category_7_pct": "0.10", "ifra_max_use_level_category_11_pct": "0.018", "eu_allergen_declaration_required": "No", "eu_26_allergens_list": "Proposed", "sccs_opinion_available": "Yes", "sensitiza…

preservative

{"preservative_class": "Phenol derivative", "antimicrobial_spectrum_bacteria_gp": "Excellent", "antimicrobial_spectrum_bacteria_gn": "Excellent", "antimicrobial_spectrum_yeast": "Yes", "antimicrobial_spectrum_mold": "Yes", "mic_staph_aureus_ppm": "50", "mic_e_coli_ppm": "50", "mic_pseudomonas_ppm": "50", "mic_candida_albicans_ppm": "200", "mic_aspergillus_niger_ppm": "200", "challenge_test_pass_co…

PubChem Annotations

Safety and regulatory annotations from PubChem (NCBI) aggregated sources.

Safety (2)

Endocrine Disruptors

Potential endocrine disrupting compound

Source: NORMAN Suspect List Exchange

Skin Eye Respiratory Irritation

...thymol is corrosive to the skin and eye. | In humans, thymol on its own or as an ingredient in combination preparations, considering its wide use, has led to primary skin irritation ... .

Source: Hazardous Substances Data Bank (HSDB)

Regulatory (6)

JECFA Number

709