Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for Thymol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOEL | 8 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >667 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 0.42 mg/kg bw/day | 1992 | mouse | inhalation | REACH |
| NOAEL | 500 other | oral | rat | oral | REACH |
| NOAEL | 61.55 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 8 other | oral | rat | oral | REACH |
Sensitization Profile
Contact sensitization data for Thymol based on clinical patch test studies and IFRA standards.
Source: IVDK; literature review
Expert Verdict
Thymol is generally considered safe for use in cosmetics with established CosIng functions.
Regulatory Flags
Frequently Asked Questions
Is Thymol safe in cosmetics?
Thymol is generally considered safe for use in cosmetics with established CosIng functions. The EU classifies Thymol as "permitted". Safety rating: GOOD. 8 toxicological study endpoint(s) are available in our database.
Is Thymol allowed in the EU?
Thymol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Thymol do in cosmetics?
Thymol functions as: Thymol is assigned two official CosIng functions. It is classified as a Cosmetic Ingredient in our database. CAS number: 89-83-8.
What is the Margin of Safety for Thymol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Thymol?
The NOAEL (No Observed Adverse Effect Level) for Thymol is 1000 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 8 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Thymol compliance across multiple jurisdictions:
Related Ingredients
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