Also known as: Bicyclo[7.2.0]undec-4-ene, 4,11,11-trimethyl-8-methylene-, (1R,4E,9S)-, (-)-(E)-Caryophyllene, (-)-Caryophyllene, Bicyclo(7.2.0)undec-4-ene, 4,11,11-trimethyl-8-methylene-, (1R-(1R*,4E,9S*))-, beta-Caryophyllen (+10 more)
INCI: TRIMETHYL-8-METHYLENEBICYCLO-4-UNDECENE
Trimethyl-8-methylenebicyclo-4-undecene (CAS 87-44-5) is a cosmetic cosmetic ingredient functioning as Perfuming / Fragrance ingredient; also recognized for anti-inflammatory/CB2. Reported NOAEL =200 mg/kg bw/day in Rat (EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
US NotesGRAS (Generally Recognized as Safe) as food flavoring; permitted in cosmetics; no restriction
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Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Trimethyl-8-methylenebicyclo-4-undecene.
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Toxicological Studies
2 study endpoints found for Trimethyl-8-methylenebicyclo-4-undecene. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
Endpoint
Value
Route
Species
Study Type
Source
NOAEL
=200 mg/kg bw/day
oral: feed
Rat
subchronic
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx
NOAEL
=200 mg/kg bw/day
oral: feed
Rat
subchronic
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
Test Type
N
Sensitized
Dose µg/cm²
NESIL µg/cm²
Potency
HRIPT
104
0
768
768
non-sensitizer
HMT
-
0
2592
-
-
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1324
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
beta-CARYOPHYLLENE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/64 | FAS 54-JECFA 63/235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
DeodorizerDyeFlavouring and nutrientFragranceSoftener and conditioner
Regulatory List Membership (3)
IFRA Fragrance Transparency ListFDA Substances Added to Food (EAFUS)Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Trimethyl-8-methylenebicyclo-4-undecene.
FragranceDeodorizerSoftener and conditionerFlavouring and nutrient
Regulatory Lists
IFRA TransparencyEuropefood_additive; Substances Added to Food (formerly EAFUS) (2/2019)detected; Europe; Personal care - sexual wellnessdetected; Europe; Personal care - sexual wellnessdetected; Europe; Personal care - linimentEurope; Personal care - linimentEurope; nondetect; Personal care - sexual wellnessconsumer_product
Australian Status
AICIS status:listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCEChEMBL / DrugCentral / FAERSDB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Is Trimethyl-8-methylenebicyclo-4-undecene safe in cosmetics?
Trimethyl-8-methylenebicyclo-4-undecene has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Is Trimethyl-8-methylenebicyclo-4-undecene allowed in the EU?
Trimethyl-8-methylenebicyclo-4-undecene EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Trimethyl-8-methylenebicyclo-4-undecene do in cosmetics?
Trimethyl-8-methylenebicyclo-4-undecene functions as: Perfuming / Fragrance ingredient; also recognized for anti-inflammatory/CB2 agonist properties. It is classified as a cosmetic ingredient in our database. CAS number: 87-44-5.
What is the NOAEL for Trimethyl-8-methylenebicyclo-4-undecene?
The NOAEL (No Observed Adverse Effect Level) for Trimethyl-8-methylenebicyclo-4-undecene is =200 mg/kg bw/day based on a subchronic study via oral: feed route in Rat. A total of 2 study endpoints are available. Source: EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx.
Is Trimethyl-8-methylenebicyclo-4-undecene used outside cosmetics?
Trimethyl-8-methylenebicyclo-4-undecene also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Trimethyl-8-methylenebicyclo-4-undecene have different safety status in cosmetics vs industrial chemicals?
Trimethyl-8-methylenebicyclo-4-undecene is classified GHS Danger (H304, H317) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
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