Good Fragrance

Beta-Caryophyllene

INCI: BETA-CARYOPHYLLENE

CAS Number
87-44-5
Function
Fragrance; skin-conditioning; anti-inflammatory
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status restricted
EU Max Conc. 0.001% leave-on / 0.01% rinse-off (individually declarable above these thresholds under EU Regulation 2023/1545)
🇺🇸 US Status permitted
US Notes Permitted for cosmetic use; found in copaiba, clove, black pepper, ylang ylang, and cannabis/hemp extracts; RIFM-assessed

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Newly declarable EU allergen under EU Regulation 2023/1545 (effective 31 July 2026 for new products, 31 July 2028 for on-market products). Must be declared above 0.001% in leave-on and 0.01% in rinse-off products. Widely distributed sesquiterpene in essential oils and major constituent of hemp/cannabis extracts with relatively low sensitization potential despite allergen designation. Update formulations, CPSRs, and labels accordingly.

⚠️
Concern Level: Low

Regulatory Flags

allergen-eu eu-2023-1545-newly-listed eu-labelling-required low-sensitization hemp-cannabis-relevant anti-inflammatory ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Beta-Caryophyllene safe in cosmetics?

Newly declarable EU allergen under EU Regulation 2023/1545 (effective 31 July 2026 for new products, 31 July 2028 for on-market products). Must be declared above 0.001% in leave-on and 0.01% in rinse-off products. Widely distributed sesquiterpene in essential oils and major constituent of hemp/cannabis extracts with relatively low sensitization potential despite allergen designation. Update formulations, CPSRs, and labels accordingly. The EU classifies Beta-Caryophyllene as "restricted". Safety rating: GOOD.

Is Beta-Caryophyllene allowed in the EU?

Beta-Caryophyllene EU regulatory status: restricted. Maximum allowed concentration: 0.001% leave-on / 0.01% rinse-off (individually declarable above these thresholds under EU Regulation 2023/1545). This is based on EU Regulation 1223/2009 and its amendments.

What does Beta-Caryophyllene do in cosmetics?

Beta-Caryophyllene functions as: Fragrance; skin-conditioning; anti-inflammatory. It is classified as a Fragrance in our database. CAS number: 87-44-5.

What is the Margin of Safety for Beta-Caryophyllene?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Beta-Caryophyllene compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

Vanillin
Good
Cinnamyl Alcohol
Moderate
Atranol
Poor
Anthemis Nobilis Flower Oil
Good
Olive Oil (Olea Europaea Fruit Oil)
Good
Browse all 30,000+ ingredients →
📱

Is Beta-Caryophyllene in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Beta-Caryophyllene in your formulation.

Ingredient Decoder MoS Calculator