Is Beta-Caryophyllene safe in cosmetics?
Beta-Caryophyllene has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Beta-Caryophyllene
Also known as: Bicyclo[7.2.0]undec-4-ene, 4,11,11-trimethyl-8-methylene-, (1R,4E,9S)-, (-)-(E)-Caryophyllene, (-)-Caryophyllene, Bicyclo(7.2.0)undec-4-ene, 4,11,11-trimethyl-8-methylene-, (1R-(1R*,4E,9S*))-, beta-Caryophyllen (+10 more)
INCI: BETA-CARYOPHYLLENE
Beta-Caryophyllene (CAS 87-44-5) is a cosmetic fragrance functioning as Fragrance; skin-conditioning; anti-inflammatory. Reported NOAEL =200 mg/kg bw/day in Rat (EFSA); EU Regulation 1223/2009 status: restricted, max 0.001% leave-on / 0.01% rinse-off (individually declarable above these thresholds under EU Regulation 2023/1545). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
Cross-Vertical Regulatory Divergence
Beta-Caryophyllene is classified GHS Danger (H304, H317) in the chemicals database but is restricted in EU cosmetics at max 0.001% leave-on / 0.01% rinse-off (individually declarable above these thresholds under EU Regulation 2023/1545).
Source: Cosmetics: ingredients.eu status/eu max; Chemicals: ghs classifications.signal word/hazard statement code
Function
Fragrance; skin-conditioning; anti-inflammatory
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
(1R,4E,9S)-4,11,11-trimethyl-8-methylidenebicyclo[7.2.0]undec-4-ene
InChIKey
NPNUFJAVOOONJE-GFUGXAQUSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
0.001% leave-on / 0.01% rinse-off (individually declarable above these thresholds under EU Regulation 2023/1545)
US US Status
permitted
US Notes
Permitted for cosmetic use; found in copaiba, clove, black pepper, ylang ylang, and cannabis/hemp extracts; RIFM-assessed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Beta-Caryophyllene.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Beta-Caryophyllene. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =200 mg/kg bw/day | oral: feed | Rat | subchronic | EFSA |
| NOAEL | =200 mg/kg bw/day | oral: feed | Rat | subchronic | EFSA |
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 104 | 0 | 768 | 768 | non-sensitizer |
| HMT | - | 0 | 2592 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1324
Source: WHO/JECFA
JECFA Evaluation
beta-CARYOPHYLLENE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/64 | FAS 54-JECFA 63/235
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Dye
Flavouring and nutrient
Fragrance
Softener and conditioner
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Editorial summary
Preliminary editorial summary for Beta-Caryophyllene — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
allergen-eu
eu-2023-1545-newly-listed
eu-labelling-required
low-sensitization
hemp-cannabis-relevant
anti-inflammatory
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Beta-Caryophyllene by CAS number or substance name.
Studies
2
Lowest NOAEL
200 mg/kg bw/day
Highest NOAEL
200 mg/kg bw/day
EFSA
Known Synonyms
Bicyclo[7.2.0]undec-4-ene, 4,11,11-trimethyl-8-methylene-, (1R,4E,9S)-
(-)-(E)-Caryophyllene
(-)-Caryophyllene
Bicyclo(7.2.0)undec-4-ene, 4,11,11-trimethyl-8-methylene-, (1R-(1R*,4E,9S*))-
beta-Caryophyllen
CARYOPHYLLENE ,ALPHA + BETA MIXT.
EINECS 201-746-1
FEMA No. 2252
2-Methylene-6,10,10-trimethylbicyclo(7.2.0)undec-5-ene
8-Methylene-4,11,11-(trimethyl)bicyclo(7.2.0)undec-4-ene
4,11,11-Trimethyl-8-methylenebicyclo(7.2.0)undec-4-ene, (1R-(1R*,4E,9S))-
UNII-BHW853AU9H
(-)-beta-caryophyllene
(E)-beta-caryophyllene
trans-(1R,9S)-4,11,11-trimethyl-8-methylenebicyclo[7.2.0]undec-4-ene
Chemical Function
Fragrance
Deodorizer
Softener and conditioner
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
detected; Europe; Personal care - sexual wellness
detected; Europe; Personal care - sexual wellness
detected; Europe; Personal care - liniment
Europe; Personal care - liniment
Europe; nondetect; Personal care - sexual wellness
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
BETA-CARYOPHYLLENE
ChEMBL ID
CHEMBL445740
Max Phase
1
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
BETA-CARYOPHYLLENE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Beta-Caryophyllene allowed in the EU?
Beta-Caryophyllene EU regulatory status: restricted. Maximum allowed concentration: 0.001% leave-on / 0.01% rinse-off (individually declarable above these thresholds under EU Regulation 2023/1545). This is based on EU Regulation 1223/2009 and its amendments.
What does Beta-Caryophyllene do in cosmetics?
Beta-Caryophyllene functions as: Fragrance; skin-conditioning; anti-inflammatory. It is classified as a Fragrance in our database. CAS number: 87-44-5.
What is the NOAEL for Beta-Caryophyllene?
The NOAEL (No Observed Adverse Effect Level) for Beta-Caryophyllene is =200 mg/kg bw/day based on a subchronic study via oral: feed route in Rat. A total of 2 study endpoints are available. Source: EFSA.
Is Beta-Caryophyllene used outside cosmetics?
Beta-Caryophyllene also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Beta-Caryophyllene have different safety status in cosmetics vs industrial chemicals?
Beta-Caryophyllene is classified GHS Danger (H304, H317) in the chemicals database but is restricted in EU cosmetics at max 0.001% leave-on / 0.01% rinse-off (individually declarable above these thresholds under EU Regulation 2023/1545).
Compliance Tools
Check Beta-Caryophyllene compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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