Regulatory Status
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Safety Data
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Expert Verdict
Tripeptide-29 is a collagen-mimetic peptide presenting the native Gly-Pro-Hyp collagen repeat directly to skin cells for structural reinforcement without regulatory restrictions in EU or US, though clinical substantiation remains limited.
Regulatory Flags
Frequently Asked Questions
Is Tripeptide-29 safe in cosmetics?
Tripeptide-29 is a collagen-mimetic peptide presenting the native Gly-Pro-Hyp collagen repeat directly to skin cells for structural reinforcement without regulatory restrictions in EU or US, though clinical substantiation remains limited. The EU classifies Tripeptide-29 as "permitted". Safety rating: GOOD.
Is Tripeptide-29 allowed in the EU?
Tripeptide-29 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tripeptide-29 do in cosmetics?
Tripeptide-29 functions as: Collagen-mimetic biomimetic peptide that replicates the Gly-Pro-Hyp (glycine-proline-hydroxyproline) tripeptide sequence — the fundamental repeating unit of the collagen triple helix. Provides direct structural reinforcement and stimulates collagen synthesis by presenting a native ECM sequence to fibroblasts. Mechanism differs from signal peptides: Tripeptide-29 mimics the structural building block rather than a matrikine fragment.. It is classified as a Active Ingredient in our database. CAS number: 2239-67-0.
What is the Margin of Safety for Tripeptide-29?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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