Undecylenoyl Phenylalanine

INCI: UNDECYLENOYL PHENYLALANINE

CAS Number
175357-18-3
Function
Alpha-melanocyte-stimulating hormone (alpha-MSH) antagonist at MC1R receptor; inhibits melanin production upstream of tyrosinase by blocking MC1R stimulation and downstream cAMP-mediated MITF activation
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted as cosmetic ingredient under FDCA cosmetic provisions. Not classified as OTC drug active; not listed in FDA OTC skin bleaching monograph. No pre-market approval required.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Undecylenoyl Phenylalanine is a well-characterized skin-brightening ingredient with favorable safety profile, assessed safe as used when formulated to be non-irritating, permitted without restriction in EU and US, with multiple clinical trials confirming efficacy at 1-2% for melasma and solar lentigines.

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Concern Level: Low

Regulatory Flags

eu-unrestricted cir-approved no-sccs-opinion non-sensitizing

Frequently Asked Questions

Is Undecylenoyl Phenylalanine safe in cosmetics?

Undecylenoyl Phenylalanine is a well-characterized skin-brightening ingredient with favorable safety profile, assessed safe as used when formulated to be non-irritating, permitted without restriction in EU and US, with multiple clinical trials confirming efficacy at 1-2% for melasma and solar lentigines. The EU classifies Undecylenoyl Phenylalanine as "permitted". Safety rating: GOOD.

Is Undecylenoyl Phenylalanine allowed in the EU?

Undecylenoyl Phenylalanine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Undecylenoyl Phenylalanine do in cosmetics?

Undecylenoyl Phenylalanine functions as: Alpha-melanocyte-stimulating hormone (alpha-MSH) antagonist at MC1R receptor; inhibits melanin production upstream of tyrosinase by blocking MC1R stimulation and downstream cAMP-mediated MITF activation. It is classified as a Active Ingredient in our database. CAS number: 175357-18-3.

What is the Margin of Safety for Undecylenoyl Phenylalanine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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